Title:
METHODS FOR DETECTING DNA METHYLATION USING ENCODED PARTICLES
Document Type and Number:
WIPO Patent Application WO/2011/028533
Kind Code:
A3
Abstract:
Methods for detecting the methylation status of a target genomic locus are provided. Methods described allow for simultaneous assay of multiple cytosines in a target genomic locus. Assays of multiple cytosines in a target genomic locus provide detection of an aggregate cytosine methylation state of the target genomic locus. Methods to detect methylation of a genomic locus associated with a disease or disorder characterized by aberrant methylation of the genomic locus, such as, but not limited to, Fragile X mental retardation syndrome, Prader-Willi syndrome, Angelman sydrome, Beckwith-Wiedemann syndrome, and Russell-Silverman syndrome, diabetes, cancer, multiple sclerosis or schizophrenia are described herein.
Inventors:
MOORE JAMES K (US)
Application Number:
PCT/US2010/046508
Publication Date:
June 09, 2011
Filing Date:
August 24, 2010
Export Citation:
Assignee:
PERKINELMER HEALTH SCI INC (US)
MOORE JAMES K (US)
MOORE JAMES K (US)
International Classes:
C12Q1/68; C12N15/11; G01N33/58
Domestic Patent References:
| WO2007032748A1 | 2007-03-22 |
Foreign References:
| US20020086324A1 | 2002-07-04 |
Other References:
GITAN, R.S. ET AL.: "Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis", GENOME RES., vol. 12, no. 1, January 2002 (2002-01-01), pages 158 - 164
SHI, H. ET AL.: "Oligonucleotide-based microarray for DNA methylation analysis: principles and applications", J CELL BIOCHEM., vol. 88, no. 1, 1 January 2003 (2003-01-01), pages 138 - 143
SHI, H. ET AL.: "Oligonucleotide-based microarray for DNA methylation analysis: principles and applications", J CELL BIOCHEM., vol. 88, no. 1, 1 January 2003 (2003-01-01), pages 138 - 143
Attorney, Agent or Firm:
STAPLE, Julie, K. et al. (Krass Sprinkle, Anderson & Citkowski,P.C.,2701 Troy Center Drive, Suite 330,Post Office Box 702, Troy MI, US)
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