Title:
METHODS FOR DETERMINING THE PROPENSITY TO SUFFER HAEMORRHAGIC TRANSFORMATION FOLLOWING A STROKE
Document Type and Number:
WIPO Patent Application WO/2011/067451
Kind Code:
A3
Abstract:
The invention relates to methods for diagnosing a stroke and the risk of suffering a haemorrhagic disorder after suffering a stroke in response to treatment with an antithrombotic agent. Said methods are based on the various fluorescent properties of samples taken from patients having suffered a stroke or displaying a risk of having a stroke. The invention also provides personalised therapy methods for said patients.
Inventors:
MONTANER VILALLONGA JOAN (ES)
DOMINGUEZ LUENGO CARMEN (ES)
DOMINGUEZ LUENGO CARMEN (ES)
Application Number:
PCT/ES2010/070796
Publication Date:
August 16, 2012
Filing Date:
December 02, 2010
Export Citation:
Assignee:
FUNDACIO INST DE RECERCA HOSPITAL UNI VALL D HEBRON FUNDACIO PRIVADA (ES)
MONTANER VILALLONGA JOAN (ES)
DOMINGUEZ LUENGO CARMEN (ES)
MONTANER VILALLONGA JOAN (ES)
DOMINGUEZ LUENGO CARMEN (ES)
International Classes:
G01N33/68; G01N21/64
Domestic Patent References:
| WO2004103313A2 | 2004-12-02 | |||
| WO2006036220A2 | 2006-04-06 |
Foreign References:
| EP1733683A1 | 2006-12-20 |
Other References:
ANDREA MEZZETTI ET AL: "Vitamin E and Lipid Peroxide Plasma Levels Predict the Risk of Cardiovascular Events in a Group of Healthy Very Old People", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, vol. 49, no. 5, 1 May 2001 (2001-05-01), pages 533 - 537, XP055027840, ISSN: 0002-8614, DOI: 10.1046/j.1532-5415.2001.49110.x
G. CAIMI ET AL: "Acute Ischemic Stroke : Polymorphonuclear Leukocyte Membrane Fluidity and Cytosolic Ca2+ Concentration at Baseline and After Chemotactic Activation", STROKE, vol. 31, no. 7, 1 July 2000 (2000-07-01), pages 1578 - 1582, XP055027809, ISSN: 0039-2499, DOI: 10.1161/01.STR.31.7.1578
M. A. REYNOLDS: "Early Biomarkers of Stroke", CLINICAL CHEMISTRY, vol. 49, no. 10, 1 October 2003 (2003-10-01), pages 1733 - 1739, XP055027148, ISSN: 0009-9147, DOI: 10.1373/49.10.1733
ZARKOVIC ET AL.: "Changes of plasma peroxides in patients with stroke: Indices of differential systemic response to oxidative stress in patients with ischemic stroke or with intracerebral hemorrhage", NEUROLOGIA CROATICA, vol. 53, 2004, pages 79 - 86, XP009159568
AIRAS L ET AL: "Vascular adhesion protein-1 in human ischaemic stroke", NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON, GB, vol. 34, no. 4, 1 August 2008 (2008-08-01), pages 394 - 402, XP008146687, ISSN: 0305-1846, [retrieved on 20071114], DOI: 10.1111/J.1365-2990.2007.00911.X
KIKUGAWA ET AL: "Fluorescent products derived from the reaction of primary amines and components in peroxidized lipids", ADVANCES IN FREE RADICAL BIOLOGY & MEDICINE, PERGAMON, vol. 2, no. 2, 1 January 1986 (1986-01-01), pages 389 - 417, XP022366509, ISSN: 8755-9668, DOI: 10.1016/S8755-9668(86)80020-5
G. CAIMI ET AL: "Acute Ischemic Stroke : Polymorphonuclear Leukocyte Membrane Fluidity and Cytosolic Ca2+ Concentration at Baseline and After Chemotactic Activation", STROKE, vol. 31, no. 7, 1 July 2000 (2000-07-01), pages 1578 - 1582, XP055027809, ISSN: 0039-2499, DOI: 10.1161/01.STR.31.7.1578
M. A. REYNOLDS: "Early Biomarkers of Stroke", CLINICAL CHEMISTRY, vol. 49, no. 10, 1 October 2003 (2003-10-01), pages 1733 - 1739, XP055027148, ISSN: 0009-9147, DOI: 10.1373/49.10.1733
ZARKOVIC ET AL.: "Changes of plasma peroxides in patients with stroke: Indices of differential systemic response to oxidative stress in patients with ischemic stroke or with intracerebral hemorrhage", NEUROLOGIA CROATICA, vol. 53, 2004, pages 79 - 86, XP009159568
AIRAS L ET AL: "Vascular adhesion protein-1 in human ischaemic stroke", NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON, GB, vol. 34, no. 4, 1 August 2008 (2008-08-01), pages 394 - 402, XP008146687, ISSN: 0305-1846, [retrieved on 20071114], DOI: 10.1111/J.1365-2990.2007.00911.X
KIKUGAWA ET AL: "Fluorescent products derived from the reaction of primary amines and components in peroxidized lipids", ADVANCES IN FREE RADICAL BIOLOGY & MEDICINE, PERGAMON, vol. 2, no. 2, 1 January 1986 (1986-01-01), pages 389 - 417, XP022366509, ISSN: 8755-9668, DOI: 10.1016/S8755-9668(86)80020-5
Attorney, Agent or Firm:
ARIAS SANZ, Juan (S.L.Avenida de Burgos, 16, Edificio Euromor Madrid, ES)
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