Title:
METHODS FOR EARLY DIAGNOSIS AND TREATMENT OF OPEN NEURAL TUBE DEFECTS
Document Type and Number:
WIPO Patent Application WO/2024/040103
Kind Code:
A3
Abstract:
The present invention relates to the discovery that various proteins are enriched in the amniotic fluid of fetuses with open neural tube defects (NTDs). The invention includes methods for the diagnosis of open NTD based upon the levels and /or differential patterns of neurocan and phosphacan in a sample of the amniotic fluid or other bodily fluid of a subject.
Inventors:
KRYNSKA BARBARA (US)
Application Number:
PCT/US2023/072288
Publication Date:
May 10, 2024
Filing Date:
August 16, 2023
Export Citation:
Assignee:
UNIV TEMPLE (US)
International Classes:
C07K14/47; A61K38/00; A61L27/54; A61P25/00; C07K1/36
Other References:
ZIEBA JOLANTA, WALCZAK MACIEJ; GORDIIENKO OLEG; GERSTENHABER JONATHAN A.; SMITH GEORGE M.; KRYNSKA BARBARA: "Altered Amniotic Fluid Levels of Hyaluronic Acid in Fetal Rats with Myelomeningocele: Understanding Spinal Cord Injury", JOURNAL OF NEUROTRAUMA., M.A. LIEBERT, NEW YORK, NY., US, vol. 36, no. 12, 15 June 2019 (2019-06-15), US , pages 1965 - 1973, XP093171477, ISSN: 0897-7151, DOI: 10.1089/neu.2018.5894
MEYER‐PUTTLITZ BIRGIT, MILEV PETER; JUNKER ERNST; ZIMMER IRENE; MARGOLIS RICHARD U.; MARGOLIS RENÉE K.: "Chondroitin Sulfate and Chondroitin/Keratan Sulfate Proteoglycans of Nervous Tissue: Developmental Changes of Neurocan and Phosphacan", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 65, no. 5, 1 November 1995 (1995-11-01), GB , pages 2327 - 2337, XP093171479, ISSN: 0022-3042, DOI: 10.1046/j.1471-4159.1995.65052327.x
DATABASE NUCLEOTIDE 24 July 2016 (2016-07-24), ANONYMOUS: "Human DNA from chromosome 19-specific cosmid F14150, genomic sequence, complete sequence", XP093171436, Database accession no. AC003110.1
MEYER‐PUTTLITZ BIRGIT, MILEV PETER; JUNKER ERNST; ZIMMER IRENE; MARGOLIS RICHARD U.; MARGOLIS RENÉE K.: "Chondroitin Sulfate and Chondroitin/Keratan Sulfate Proteoglycans of Nervous Tissue: Developmental Changes of Neurocan and Phosphacan", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 65, no. 5, 1 November 1995 (1995-11-01), GB , pages 2327 - 2337, XP093171479, ISSN: 0022-3042, DOI: 10.1046/j.1471-4159.1995.65052327.x
DATABASE NUCLEOTIDE 24 July 2016 (2016-07-24), ANONYMOUS: "Human DNA from chromosome 19-specific cosmid F14150, genomic sequence, complete sequence", XP093171436, Database accession no. AC003110.1
Attorney, Agent or Firm:
BURKHARDT, Russell, N. et al. (US)
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