METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS

Title:

METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS

Document Type and Number:

WIPO Patent Application WO/2019/196924

Kind Code:

A1

Abstract:

Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

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Inventors:

ZHOU XIANGJUN (CN)
HAN YANYAN (CN)
LIANG XIAOLING (CN)
CHEN XIHE (CN)

Application Number:

PCT/CN2019/082408

Publication Date:

October 17, 2019

Filing Date:

April 12, 2019

Export Citation:

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Assignee:

SYZ CELL THERAPY CO (CN)
HRYZ SHENZHEN BIOTECH CO (CN)

International Classes:

C12N5/0783; A61K38/17; A61P35/00; C12N5/0784; C12N5/0786

Domestic Patent References:

WO2016146035A1

2016-09-22

Foreign References:

CN107530392A	2018-01-02
CN106645677A	2017-05-10

Other References:

FELIX S LICHTENEGGER; ROTHE MAURINE; SCHNORFEIL FRAUKE M; DEISER KATRIN; KRUPKA CHRISTINA; AUGSBERGER CHRISTIAN; SCHLÜTER MIRIAM; : "Targeting LAG-3 and PD- 1 to Enhance T Cell Activation by Antigen-Presenting Cells", FRONTIERS IN IMMUNOLOGY, vol. 9, 27 February 2018 (2018-02-27), pages 1 - 12, XP055480524, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00385
ZHANG LANLIN;WU XIANGHUA: "Progress in T cell receptor- gene engineered T cell immunotherapy for solid tumors", TUMOR, vol. 38, 31 March 2018 (2018-03-31), pages 256 - 263, XP055751663, ISSN: 1000-7431, DOI: 10.3781/j.issn.1000-7431.2018.55.696
See also references of EP 3775168A4

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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