Title:
METHODS FOR PRODUCING AND IDENTIFYING MULTISPECIFIC ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2005072112
Kind Code:
A3
Abstract:
The present invention relates to a high efficiency method of expressing multispecific antibodies in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for multispecific antibodies, and antigen-binding fragments thereof. The invention also provides kits for producing, screening and selecting multispecific antibodies. Finally, the invention provides multispecific antibodies , and antigen-binding fragments thereof, produced by the methods provided herein.
Inventors:
ZAUDERER MAURICE (US)
PARIS MARK (US)
PARIS MARK (US)
Application Number:
PCT/US2004/043806
Publication Date:
March 30, 2006
Filing Date:
December 30, 2004
Export Citation:
Assignee:
VACCINEX INC (US)
ZAUDERER MAURICE (US)
PARIS MARK (US)
ZAUDERER MAURICE (US)
PARIS MARK (US)
International Classes:
C12Q1/00; C07K16/00; C07K16/28; C07K16/46; C12N5/02; C12N5/06; C12N15/10; C12P21/06; C12Q1/68; G01N33/53; G01N33/68
Foreign References:
| US20020123057A1 | 2002-09-05 | |||
| US5869620A | 1999-02-09 |
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