Title:
METHODS OF THERAPY FOR B CELL-RELATED CANCERS
Document Type and Number:
WIPO Patent Application WO2005044307
Kind Code:
A3
Abstract:
Methods of treating a human subject for a cancer characterized by neoplastic B cell growth are provided. The methods comprise administering combination antibody therapy to the subject, where an effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof in combination with an anti-CD20 antibody or antigenbinding fragment thereof is administered to the subject. The invention further comprises pharmaceutical compositions with combinations of these antibodies in a pharmaceutically acceptable carrier.
Inventors:
LONG LI (US)
LUQMAN MOHAMMAD (US)
YABANNAVAR ASHA (US)
ZAROR ISABEL (US)
LUQMAN MOHAMMAD (US)
YABANNAVAR ASHA (US)
ZAROR ISABEL (US)
Application Number:
PCT/US2004/037159
Publication Date:
August 25, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
CHIRON CORP (US)
LONG LI (US)
LUQMAN MOHAMMAD (US)
YABANNAVAR ASHA (US)
ZAROR ISABEL (US)
LONG LI (US)
LUQMAN MOHAMMAD (US)
YABANNAVAR ASHA (US)
ZAROR ISABEL (US)
International Classes:
A61K39/395; C07K16/28; (IPC1-7): A61P35/02; A61K39/395
Domestic Patent References:
| WO2002028480A2 | 2002-04-11 | |||
| WO2002028940A1 | 2002-04-11 | |||
| WO2001083755A2 | 2001-11-08 | |||
| WO2002088186A1 | 2002-11-07 | |||
| WO2003029296A1 | 2003-04-10 | |||
| WO2002004021A1 | 2002-01-17 | |||
| WO2002022212A2 | 2002-03-21 |
Other References:
FUNAKOSHI S ET AL: "DIFFERENTIAL IN VITRO AND IN VIVO ANTITUMOR EFFECTS MEDIATED BY ANTI-CD40 AND ANTI-CD20 MONOCLONAL ANTIBODIES AGAINST HUMAN B-CELL LYMPHOMAS", JOURNAL OF IMMUNOTHERAPY: WITH EMPHASIS ON TUMOR IMMUNOLOGY, RAVEN PRESS, US, vol. 19, no. 2, March 1996 (1996-03-01), pages 93 - 101, XP001064650, ISSN: 1067-5583
MALONEY D G ET AL: "IDEC-C2B8: RESULTS OF A PHASE I MULTIPLE-DOSE TRIAL IN PATIENTS WITH RELAPSED NON-HODGKIN'S LYMPHOMA", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 15, no. 10, October 1997 (1997-10-01), pages 3266 - 3274, XP002936242, ISSN: 0732-183X
MALONEY D G ET AL: "IDEC-C2B8: RESULTS OF A PHASE I MULTIPLE-DOSE TRIAL IN PATIENTS WITH RELAPSED NON-HODGKIN'S LYMPHOMA", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 15, no. 10, October 1997 (1997-10-01), pages 3266 - 3274, XP002936242, ISSN: 0732-183X
Download PDF: