Title:
METHYLTRANSFERASES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/108126
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for biomarker screening and research. In particular, the present invention relates to VCP-KMT methyltransferases, antibodies to methylated VCP, and targets of VCP-KMT for screening and research applications.
Inventors:
FALNES PAL OYSTEIN (NO)
KERNSTOCK STEFAN (NO)
KLUNGLAND ARNE (NO)
FUSSER MARKUS (NO)
KERNSTOCK STEFAN (NO)
KLUNGLAND ARNE (NO)
FUSSER MARKUS (NO)
Application Number:
PCT/IB2013/000420
Publication Date:
December 27, 2013
Filing Date:
January 14, 2013
Export Citation:
Assignee:
UNIV OSLO (NO)
UNIV OSLO HF (NO)
FALNES PAL OYSTEIN (NO)
KERNSTOCK STEFAN (NO)
KLUNGLAND ARNE (NO)
FUSSER MARKUS (NO)
UNIV OSLO HF (NO)
FALNES PAL OYSTEIN (NO)
KERNSTOCK STEFAN (NO)
KLUNGLAND ARNE (NO)
FUSSER MARKUS (NO)
International Classes:
C12Q1/48; A61K39/00; G01N33/574
Other References:
STEVEN G. GRAY: "Targeting Histone Deacetylases for the Treatment of Huntington's Disease", CNS NEUROSCIENCE & THERAPEUTICS, vol. 16, no. 6, 9 December 2010 (2010-12-09), pages 348 - 361, XP055068057, ISSN: 1755-5930, DOI: 10.1111/j.1755-5949.2010.00184.x
KLARA ACS ET AL: "The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 18, no. 12, 27 November 2011 (2011-11-27), pages 1345 - 1350, XP055068064, ISSN: 1545-9993, DOI: 10.1038/nsmb.2188
PHILIPPE CLOUTIER ET AL: "A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity", PLOS GENETICS, vol. 9, no. 1, E1003210, 1 January 2013 (2013-01-01), pages 1 - 13, XP055068524, ISSN: 1553-7390, DOI: 10.1371/journal.pgen.1003210
KERNSTOCK STEFAN ET AL: "Lysine methylation of VCP by a member of a novel human protein methyltransferase family.", NATURE COMMUNICATIONS, vol. 3, 1038, 2012, XP002701165, ISSN: 2041-1723
NANDO DULAL DAS ET AL: "Sodium arsenite dependent protein expression analysis on human embryonic carcinoma (NCCIT) cell line", TOXICOLOGY LETTERS, vol. 207, no. 2, 2 September 2011 (2011-09-02), ELSEVIER BIOMEDICAL PRESS, AMSTERDAM, NL, pages 149 - 158, XP028312727, ISSN: 0378-4274, [retrieved on 20110908], DOI: 10.1016/J.TOXLET.2011.09.003
VIJ NEERAJ: "AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 12, no. 6A, December 2008 (2008-12-01), pages 2511 - 2518, XP002701166, ISSN: 1582-1838, DOI: 10.1111/j.1582-4934.2008.00462.x
BRAUN R J ET AL: "Mechanisms of Cdc48/VCP-mediated cell death - from yeast apoptosis to human disease", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, vol. 1783, no. 7, 1 July 2008 (2008-07-01), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, pages 1418 - 1435, XP022715887, ISSN: 0167-4889, [retrieved on 20080202], DOI: 10.1016/J.BBAMCR.2008.01.015
DOOLAN PADRAIG ET AL: "Microarray and Proteomics Expression Profiling Identifies Several Candidates, Including the Valosin-Containing Protein (VCP), Involved in Regulating High Cellular Growth Rate in Production CHO Cell Lines", BIOTECHNOLOGY AND BIOENGINEERING, vol. 106, no. 1, May 2010 (2010-05-01), pages 42 - 56, XP002701167, DOI: 10.1002/bit.22670
NALBANDIAN ANGELE ET AL: "The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology", PLOS ONE, vol. 7, no. 9, E46308, September 2012 (2012-09-01), pages 1 - 10, XP002701168
KLARA ACS ET AL: "The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 18, no. 12, 27 November 2011 (2011-11-27), pages 1345 - 1350, XP055068064, ISSN: 1545-9993, DOI: 10.1038/nsmb.2188
PHILIPPE CLOUTIER ET AL: "A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity", PLOS GENETICS, vol. 9, no. 1, E1003210, 1 January 2013 (2013-01-01), pages 1 - 13, XP055068524, ISSN: 1553-7390, DOI: 10.1371/journal.pgen.1003210
KERNSTOCK STEFAN ET AL: "Lysine methylation of VCP by a member of a novel human protein methyltransferase family.", NATURE COMMUNICATIONS, vol. 3, 1038, 2012, XP002701165, ISSN: 2041-1723
NANDO DULAL DAS ET AL: "Sodium arsenite dependent protein expression analysis on human embryonic carcinoma (NCCIT) cell line", TOXICOLOGY LETTERS, vol. 207, no. 2, 2 September 2011 (2011-09-02), ELSEVIER BIOMEDICAL PRESS, AMSTERDAM, NL, pages 149 - 158, XP028312727, ISSN: 0378-4274, [retrieved on 20110908], DOI: 10.1016/J.TOXLET.2011.09.003
VIJ NEERAJ: "AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 12, no. 6A, December 2008 (2008-12-01), pages 2511 - 2518, XP002701166, ISSN: 1582-1838, DOI: 10.1111/j.1582-4934.2008.00462.x
BRAUN R J ET AL: "Mechanisms of Cdc48/VCP-mediated cell death - from yeast apoptosis to human disease", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, vol. 1783, no. 7, 1 July 2008 (2008-07-01), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, pages 1418 - 1435, XP022715887, ISSN: 0167-4889, [retrieved on 20080202], DOI: 10.1016/J.BBAMCR.2008.01.015
DOOLAN PADRAIG ET AL: "Microarray and Proteomics Expression Profiling Identifies Several Candidates, Including the Valosin-Containing Protein (VCP), Involved in Regulating High Cellular Growth Rate in Production CHO Cell Lines", BIOTECHNOLOGY AND BIOENGINEERING, vol. 106, no. 1, May 2010 (2010-05-01), pages 42 - 56, XP002701167, DOI: 10.1002/bit.22670
NALBANDIAN ANGELE ET AL: "The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology", PLOS ONE, vol. 7, no. 9, E46308, September 2012 (2012-09-01), pages 1 - 10, XP002701168
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