Title:
MICRO-RNA MOLECULES
Document Type and Number:
WIPO Patent Application WO2003029459
Kind Code:
A3
Abstract:
In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as "small temporal RNAs" (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRNA, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
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Inventors:
TUSCHL THOMAS (DE)
LAGOS-QUINTANA MARIANA (DE)
LENDECKEL WINFRIED (DE)
MEYER JUTTA (DE)
RAUHUT REINHARD (DE)
LAGOS-QUINTANA MARIANA (DE)
LENDECKEL WINFRIED (DE)
MEYER JUTTA (DE)
RAUHUT REINHARD (DE)
Application Number:
PCT/EP2002/010881
Publication Date:
November 27, 2003
Filing Date:
September 27, 2002
Export Citation:
Assignee:
MAX PLANCK GES ZUR (DE)
TUSCHL THOMAS (DE)
LAGOS-QUINTANA MARIANA (DE)
LENDECKEL WINFRIED (DE)
MEYER JUTTA (DE)
RAUHUT REINHARD (DE)
TUSCHL THOMAS (DE)
LAGOS-QUINTANA MARIANA (DE)
LENDECKEL WINFRIED (DE)
MEYER JUTTA (DE)
RAUHUT REINHARD (DE)
International Classes:
A61K48/00; C12N15/09; A61P35/02; C12N15/113; A61K38/00; (IPC1-7): C12N15/11; A61K48/00
Other References:
PASQUINELLI AMY E ET AL: "Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 408, no. 6808, 2000, pages 86 - 89, XP002204652, ISSN: 0028-0836
REINHART BRENDA J ET AL: "The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.", NATURE (LONDON), vol. 403, no. 6772, 24 February 2000 (2000-02-24), pages 901 - 906, XP002229063, ISSN: 0028-0836
MOSS ERIC G ET AL: "The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.", CELL, vol. 88, no. 5, 1997, pages 637 - 646, XP002229064, ISSN: 0092-8674
REINHART BRENDA J ET AL: "The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.", NATURE (LONDON), vol. 403, no. 6772, 24 February 2000 (2000-02-24), pages 901 - 906, XP002229063, ISSN: 0028-0836
MOSS ERIC G ET AL: "The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.", CELL, vol. 88, no. 5, 1997, pages 637 - 646, XP002229064, ISSN: 0092-8674
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