Title:
MICROENCAPSULATED SUSTAINED-RELEASE PREPARATION AND PRODUCTION
Document Type and Number:
WIPO Patent Application WO/1992/004891
Kind Code:
A1
Abstract:
A microencapsulated sustained-release preparation comprising a physiologically active substance as the core and a biocompatible polymer which is decomposable in vivo and/or is compatible with the tissues in vivo as the shell, said preparation being produced from a W/O/W emulsion which is prepared by first preparing a W/O emulsion from an aqueous solution of the physiologically active substance and a solution of the biocompatible polymer in an organic solvent, and conducting secondary emulsification between the W/O emulsion and an aqueous solution of a water-soluble polymer in the presence of a salt substance with the concentration of 0.1 M or saturation concentration in the outer water layer. The microcapsule has a maximum particle diameter of 150 mum or less, a mean particle diameter of 5 to 100 mum, and a coefficient of variation of the particle diameter of 50% or less, so that it can be used as an injection as such without the necessity for conducting particular fractionation and particle size adjustment.
Inventors:
ARAKAWA MASAYUKI (JP)
UCHIO TAKASHI (JP)
SATO YASUSHI (JP)
UCHIO TAKASHI (JP)
SATO YASUSHI (JP)
Application Number:
PCT/JP1991/001224
Publication Date:
April 02, 1992
Filing Date:
September 13, 1991
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K9/16; A61K9/52; A61K9/58; B01J13/12; (IPC1-7): A61K9/52; A61K9/58
Foreign References:
| JPS4310863B1 | ||||
| JPS469836B1 | ||||
| JPS4933738B1 | 1974-09-09 | |||
| JPS4912024A | 1974-02-02 | |||
| JPS5793912A | 1982-06-11 | |||
| JPS5094112A | 1975-07-26 | |||
| JPS63233926A | 1988-09-29 | |||
| JPS62201816A | 1987-09-05 |
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