MICROENCAPSULATION AND SUSTAINED RELEASE OF BIOLOGICALLY ACTIVE AGENT

Title:

MICROENCAPSULATION AND SUSTAINED RELEASE OF BIOLOGICALLY ACTIVE AGENT

Document Type and Number:

WIPO Patent Application WO2001058474

Kind Code:

A3

Abstract:

This invention relates to sustained release compositions, and methods of forming and using said compositions, for the sustained release of biologically active acid-stable or free sulfhydryl-containing proteins, in particular beta -IFN. The sustained release composition of this invention comprises a biocompatible polymer having dispersed therein a stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation and a nonionic polymer surfactant. The method of the invention, for forming a composition for the sustained release of biologically active acid-stable or free sulfhydryl-containing protein, in particular beta -IFN, includes dissolving a polymer in a polymer solvent to form a polymer solution, adding a stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation and a nonionic surfactant to the polymer solution, and then solidifying the polymer to form a polymer matrix containing the stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation, and a nonionic surfactant. The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active acid-stable or free sulfhydryl-containing protein in a subject for a sustained period by administering to the subject a dose of the sustained release composition described herein.

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Inventors:

TRACY MARK A (US)
WARD KEVIN L (US)
SCHER DAVID S (US)
JOHNSON J KEITH (US)

Application Number:

PCT/US2001/003160

Publication Date:

February 14, 2002

Filing Date:

January 31, 2001

Export Citation:

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Assignee:

ALKERMES INC (US)
TRACY MARK A (US)
WARD KEVIN L (US)
SCHER DAVID S (US)
JOHNSON J KEITH (US)

International Classes:

A61K9/16; A61K38/00; A61K38/21; A61K47/12; A61K47/16; A61K47/18; A61K47/26; A61K47/28; A61K47/34; A61K47/36; A61K47/38; (IPC1-7): A61K38/21; A61K9/16; A61K47/34

Domestic Patent References:

WO1996028143A1	1996-09-19
WO1991012882A1	1991-09-05
WO1998027963A2	1998-07-02
WO1996003116A1	1996-02-08
WO1999024061A1	1999-05-20

Foreign References:

EP0251476A1	1988-01-07
FR2620621A1	1989-03-24

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