Title:
MICROSCALE ROBOTS FOR DRUG DELIVERY THROUGH VISCOUS FLUIDS
Document Type and Number:
WIPO Patent Application WO/2022/216698
Kind Code:
A3
Abstract:
The present invention is related to the field of microrobotics. In particular, microscale actuators are contemplated that are L-shaped microparticle dimers and configured to self-propel through non-Newtonian viscous fluids in a time-asymmetric cyclic magnetic field, thereby providing an improved therapeutic agent delivery platform. The microscale robots can be used to treat any condition associated with non-Newtonian fluids such as pulmonary conditions including, but not limited to chronic obstructive pulmonary disease, cystic fibrosis and/or viral infections.
Inventors:
SHIELDS CHARLES (US)
MINNIS MONTANA (US)
MINNIS MONTANA (US)
Application Number:
PCT/US2022/023468
Publication Date:
December 08, 2022
Filing Date:
April 05, 2022
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
International Classes:
A61K8/11; G02F1/05; G02F1/16757
Other References:
HAN KOOHEE, SHIELDS CHARLES WYATT, BHARTI BHUVNESH, ARRATIA PAULO E., VELEV ORLIN D.: "Active Reversible Swimming of Magnetically Assembled “Microscallops” in Non-Newtonian Fluids", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 36, no. 25, 30 June 2020 (2020-06-30), US , pages 7148 - 7154, XP093012192, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.9b03698
HAN KOOHEE, SHIELDS C. WYATT, VELEV ORLIN D.: "Engineering of Self‐Propelling Microbots and Microdevices Powered by Magnetic and Electric Fields", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 28, no. 25, 1 June 2018 (2018-06-01), DE , XP093012197, ISSN: 1616-301X, DOI: 10.1002/adfm.201705953
HAN KOOHEE, SHIELDS C. WYATT, VELEV ORLIN D.: "Engineering of Self‐Propelling Microbots and Microdevices Powered by Magnetic and Electric Fields", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 28, no. 25, 1 June 2018 (2018-06-01), DE , XP093012197, ISSN: 1616-301X, DOI: 10.1002/adfm.201705953
Attorney, Agent or Firm:
HOWERTON, Thomas, C. et al. (US)
Download PDF: