MICROSPHERE DELIVERY OF MUCIN PEPTIDES

Title:

MICROSPHERE DELIVERY OF MUCIN PEPTIDES

Document Type and Number:

WIPO Patent Application WO2002062319

Kind Code:

A3

Abstract:

A mucin peptide, such as MUC-1, encapsulated in a biodegradable polymeric microsphere is disclosed. The encapsulated mucin peptid e breaks tolerance of helper T cells as it elicits a stronger immune response and provides improved protection against tumor challenge than direct administration of peptide, alone or with an adjuvant. The encapsulated mucin peptide can be used in a vaccine composition, and can be used in a method for delivering a mucin peptide to a subject, as well as in a method treating or preventing a cancer associated with reduced glycosylation of MUC-1.

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Inventors:

JOHNSON MARK E
CECIL TRICIA
FINN OLIVERA J

Application Number:

PCT/US2002/001852

Publication Date:

March 27, 2003

Filing Date:

January 22, 2002

Export Citation:

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Assignee:

CORIXA CORP (US)

International Classes:

A61K9/16; A61K38/17; A61K39/00; A61K9/00; (IPC1-7): A61K9/16; A61K38/17

Domestic Patent References:

WO1995003825A1	1995-02-09
WO1998010783A1	1998-03-19

Other References:

DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NEWMAN, KIMBERLEY D. ET AL: "Delivery of MUC1 mucin peptide by poly(d,l-lactic-co-glycolic acid) microspheres induces Type 1 T-helper immune responses", XP002217048, retrieved from STN Database accession no. 129:280894 CA

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