Title:
MIRNAS, COMPOSITIONS, AND METHODS OF USING THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/202854
Kind Code:
A1
Abstract:
A method for identifying a patient as having a marker correlated with systemic lupus erythematosus (SLE) comprises obtaining a body fluid sample from a patient suspected of having SLE, analyzing miRNA expression in the obtained body fluid sample, and identifying the patient as having the marker correlated with SLE if an increase in expression of at least one miRNA selected from SEQ ID NOs: 1-160 and 243-402 and/or a decrease in expression of at least one miRNA selected from SEQ ID NOs: 161-242 and 403-484 compared to a body fluid sample obtained from a healthy individual is detected in the patient sample, or as not having the marker correlated with SLE if an increase in expression of at least one miRNA selected from SEQ ID NOs: 1-160 and 243-402 and/or a decrease in expression of at least one miRNA selected from SEQ ID NOs: 161-242 and 403-484 compared to a body fluid sample obtained from a healthy individual fails to be detected.
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Inventors:
YAMAGUCHI HIROKI (JP)
Application Number:
PCT/JP2022/013311
Publication Date:
September 29, 2022
Filing Date:
March 22, 2022
Export Citation:
Assignee:
CRAIF INC (JP)
International Classes:
C12Q1/68; A61K39/395; A61P29/00; A61P37/02; C12M1/00; C12N15/09; C12N15/113; G01N33/50
Domestic Patent References:
| WO2021049671A1 | 2021-03-18 |
Foreign References:
| US20200164375A1 | 2020-05-28 |
Other References:
JAVIER PEREZ-HERNANDEZ, FORNER MARIA, PINTO CAROLINA, CHAVES FELIPE, CORTES RAQUEL, REDON JOSEP, ALVAREZ: "Increased Urinary Exosomal MicroRNAs in Patients with Systemic Lupus Erythematosus", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 9, 21 September 2015 (2015-09-21), pages e0138618, XP055256629, DOI: 10.1371/journal.pone.0138618
ABE SEIICHIRO; MATSUZAKI JUNTARO; SUDO KAZUKI; ODA ICHIRO; KATAI HITOSHI; KATO KEN; TAKIZAWA SATOKO; SAKAMOTO HIROMI; TAKESHITA FU: "A novel combination of serum microRNAs for the detection of early gastric cancer", GASTRIC CANCER, SPRINGER SINGAPORE, SINGAPORE, vol. 24, no. 4, 20 March 2021 (2021-03-20), Singapore, pages 835 - 843, XP037481375, ISSN: 1436-3291, DOI: 10.1007/s10120-021-01161-0
UENO MORIO, ASADA KAZUKO, TODA MUNETOYO, SCHLÖTZER-SCHREHARDT URSULA, NAGATA KAZUE, MONTOYA MONTY, SOTOZONO CHIE, KINOSHITA SHIGER: "Gene Signature–Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 57, no. 10, 23 August 2016 (2016-08-23), US , pages 4295, XP055970360, ISSN: 1552-5783, DOI: 10.1167/iovs.16-19806
LI FANNIAN, LI HAITAO, LI SHUAI, LV BAOLEI, SHI JUNJIE, YAN HONGJIANG, ZHANG HELIN, HE YUZHENG: "miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3", PHARMACOGENOMICS, FUTURE MEDICINE, UK, vol. 21, no. 11, 1 July 2020 (2020-07-01), UK , pages 771 - 783, XP009539830, ISSN: 1462-2416, DOI: 10.2217/pgs-2020-0006
ABE SEIICHIRO; MATSUZAKI JUNTARO; SUDO KAZUKI; ODA ICHIRO; KATAI HITOSHI; KATO KEN; TAKIZAWA SATOKO; SAKAMOTO HIROMI; TAKESHITA FU: "A novel combination of serum microRNAs for the detection of early gastric cancer", GASTRIC CANCER, SPRINGER SINGAPORE, SINGAPORE, vol. 24, no. 4, 20 March 2021 (2021-03-20), Singapore, pages 835 - 843, XP037481375, ISSN: 1436-3291, DOI: 10.1007/s10120-021-01161-0
UENO MORIO, ASADA KAZUKO, TODA MUNETOYO, SCHLÖTZER-SCHREHARDT URSULA, NAGATA KAZUE, MONTOYA MONTY, SOTOZONO CHIE, KINOSHITA SHIGER: "Gene Signature–Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 57, no. 10, 23 August 2016 (2016-08-23), US , pages 4295, XP055970360, ISSN: 1552-5783, DOI: 10.1167/iovs.16-19806
LI FANNIAN, LI HAITAO, LI SHUAI, LV BAOLEI, SHI JUNJIE, YAN HONGJIANG, ZHANG HELIN, HE YUZHENG: "miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3", PHARMACOGENOMICS, FUTURE MEDICINE, UK, vol. 21, no. 11, 1 July 2020 (2020-07-01), UK , pages 771 - 783, XP009539830, ISSN: 1462-2416, DOI: 10.2217/pgs-2020-0006
Attorney, Agent or Firm:
AKATSU Takeshi (JP)
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