Title:
MODIFIED TRANSFERRIN FUSION PROTEINS COMPRISING DUPLICATE TRANSFERRIN AMINO OR CARBOXY TERMINAL DOMAINS
Document Type and Number:
WIPO Patent Application WO2004020454
Kind Code:
A3
Abstract:
Fusion proteins of transferrin and other therapeutic moieties with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.
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Inventors:
TURNER ANDREW J (US)
SADEGHI HOMAYOUN (US)
SADEGHI HOMAYOUN (US)
Application Number:
PCT/US2003/026742
Publication Date:
November 04, 2004
Filing Date:
August 28, 2003
Export Citation:
Assignee:
BIOREXIS PHARMACEUTICAL CORP (US)
TURNER ANDREW J (US)
SADEGHI HOMAYOUN (US)
TURNER ANDREW J (US)
SADEGHI HOMAYOUN (US)
International Classes:
A61K47/48; C07K7/06; C07K7/08; C07K14/705; C07K14/79; A61K38/00; (IPC1-7): A61K39/00
Other References:
DATABASE GENBANK [online] 25 November 1994 (1994-11-25), JACOBS E. ET AL: "Human transferrin precursor", XP002903253, Database accession no. (AAR66492)
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