Backeroulld of the Invention Polyolefins, inciuding polypropylene, are used in a variety of industrial applications. For some of these applications, such as packaging, storage containers, disposable medical devices, and so on, it is necessary or desirable that the product or article be optically clear. The optical and physical properties of the polyolefins are largely dependent upon the number of nucleation sites and the rate of nucleation during the crystallization process. The nucleation step of the overall crystallization process for polyolefins such as stabilized polypropylene is generally slow, so that a relatively small number of nucleation sites are formed. These nucleation sites are the points at which spherulites start to grow during the subsequent crystallization step. Because the number of sites is low, the spherulites can grow to a large size.

When the size of the spherulites is larger than the wavelength of incident light, the light scatters and the polyolefin has a hazy appearance.

The size of the spherulites can be reduced and the optical properties of the polyolefin improved by the addition of nucleating and/or clarifying agents ("modifying agents") during processing. These agents increase the number of nucleation sites, and therefore the rate of nucleation. The size of the spherulites that form at these sites is smaller and the spherulites are more numerous as a result of this heterogeneous nucleation. If the spherulites are smaller in size than the

wavelength of incident light, scattering of the light is substantially reduced and the resin appears clear.

Reduction of spherulite size also affects the physical properties of the polyolefin, e.g. flexural modulus, heat distortion temperature, impact strength and elongation at break of the resin can change with the addition of a modifying agent.

The enhanced heterogeneous nucleation raises the crystallization onset temperature of the resin. This can result in a reduced cycle time during processing and greater manufacturing efficiency.

Nucleating and clarifying agents are generally known in the polymer art.

U.S. Patent No. 5,135,975 describes clarifying agents commercially known as the MilladTM group of products produced by Milliken Chemicals. These additives, particularly MilladTM 3988 have good organoleptic properties and resist plate-out, but dispersion problems resulting in the appearance of white specks have been encountered by some users. Relatively high process temperatures are needed to prevent the appearance of these white specks. Related clarifiers are described in JP 57-018682 and in JP 86-017834.

U.S. Patent No. 5,342,868 describes the use of various organophosphorus salts as clarifiers for various crystalline synthetic resins. These additives perform well but their higher cost makes them somewhat less economical for use on a large scale.

There is a need in the art for agents that can be added to polyolefins such as polypropylene that are compatible with the polyolefin and stable under polyolefin processing conditions, that improve the optical and/or physical properties of the polyolefin, and that may be efficiently obtained or produced.

Summat of the Invention We have found that compounds of formulas (I) and (II), and salts thereof are useful modifying agents for polyolefins, especially as nucleating and/or clarifying agents:

wherein X and Y are independently C1-18 alkylene, C2-18 alkenylene, This cycloalkylene, C4-s cycloalkenylene, or arylene; R1 and R2 are independently -H, C1-18 alkyl, or -CORS; R3 and R4 together form -A-B-C-, wherein A and C are independently -o-) -CR6R7-, or -CR6-; and B is a single or double bond, or when neither A nor C is -O-, B can be -O-; R5 is -OH, -O-C1-18alkyl, -O-aryl, or -NRR'; each R6 and R7 is independently -H, halogen, C1-18 alkyl,

C3-18 cycloalkyl, -CORS, -CRR'-CORS, or -NRR'; each R and R' is independently -H, C1.18 alkyl, C3-,8 cycloalkyl, or C1.18 alkyl substituted by one or more -OH, halogen,-COOH, COOC1.18 alkyl, C1-18alkylene-S-C1-18alkyl, aryl, or substituted aryl groups; or a salt thereof; wherein each R8 is independently a -H or C1.18 alkyl group or a salt thereof Accordingly, the invention provides compositions comprising a polyolefin and an effective nucleating and/or clarifying amount of a compound of formula (I) or (II), or a salt thereof.

The invention further provides a method of enhancing the crystallinity of a polyolefin by adding an effective amount of a compound of formula (I) or (II), or a salt thereof, to the polyolefin.

The compounds of formula (I) and (1I) act as modifying agents, e.g.

nucleating and/or clarifying agents, for polyolefins. A nucleating agent acts to improve the physical properties of the polyolefin such as strength, weatherability,

solvent resistance, heat deflection temperature and so on by providing sites for crystal formation, resulting in formation of increased numbers of spherulites. If the spherulites are sufficiently large to scatter visible light, the polyolefin material will not be optically clear. A clarifying agent provides compositions that are more optically clear by causing the formation of spherulites that are sufficiently small that they scatter less ambient light. Generally, the different physical properties of the polyolefin such as the yield stress and impact resistance tend to vary as the spherulites become smaller in size, so that the desired optical clarity and physical properties should be balanced when determining the type and amount of modifying agent to use.

Detailed Description of the Invention The modifying agents ofthe invention are compounds of formula (I) or (II): wherein X and Y are independently Cl l8 alkylene, C2.18 alkenylene, C3-,8 cycloalkylene, C4-,8 cycloalkenylene, or arylene; R1 and R2 are independently -H, C1.18 alkyl, or -COR5; R3 and R4 together form -A-B-C-, wherein A and C are independently -O- -CR6R7-, or -CR6-; and B is a single or double bond, or when neither A nor C is -O-, B can be -O-; R5 is -OH, -O-C, ,8 alkyl, -O-aryl, or -NRR'; each R6 and R7 is independently -H, halogen, C1-18 alkyl, C3-,8 cycloalkyl, -COR5, -CRR'-COR5, or -NRR'; each R and R' is independently -H, C1-18 alkyl, This cycloalkyl, or C1-18alkyl substituted by one or more -OH, halogen, -COOH, COOC1.18 alkyl, C1-18 alkylene-S-C1-18 alkyl, aryl, or substituted aryl groups, or a salt thereof;

wherein each R8 is independently a -H or C,-,8 alkyl group or a salt thereof.

In the above formulas, each alkyl, alkenyl, alkylene and alkenylene group can be straight or branched. For example, "C1.18 alkyl" includes methyl, ethyl, n- propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, and so on. The cycloalkyl, cycloalkenyl, aryl, cycloalkylene, cycloalkenylene, and arylene groups include those groups that are alkyl substituted, up to the specified number of carbon atoms.

"Aryl" includes carbocyclic and heterocyclic aryl, but is preferably carbocyclic aryl, most preferably phenyl.

The anhydrides of formula (tri) include those formed intramolecularly, that is between two of the -COOH groups on the cyclohexane ring.

Some compounds useful in the invention contain one or more chiral centers.

In this instance the invention includes each enantiomer or diastereomer as well as mixtures (e.g. racemic mixtures) ofthe enantiomers or diastereomers.

Of the various possible salt forums of the compounds of formula (I) and (II), the Nat, Lit, NH and Zn2 salts are generally preferred.

A preferred class of modifying agents includes the compounds of formula (I) wherein X and Y are both C,-,8 alkylene.

One particularly preferred modifying agent is camphanic acid and its salts.

Camphanic acid has the following structure:

Ammonium camphanoate is a preferred salt form of camphanic acid.

Another preferred modifying agent is that of formula (III) below: The modifying agent can be included in a composition of the present invention in an amount sufficient to provide desired optical and/or physical properties to the composition. Preferably the modifying agent can be present in an amount in the range from about 0.001 to 1 wt-% based on the total composition weight, more preferably from about 0.15 to 0.7 wt-%.

The modifying agents useful in the invention are known and commercially available, or can be readily synthesized by methods known in the chemical art. For example, camphanic acid is available from Aldrich Chemical Company, Inc., Milwaukee, Wisconsin or can be synthesized according to the procedure described in OrR. Svnth., 71, p. 48 (1992). Derivatives of camphanic acid can be prepared as desired. Other compounds can be prepared using the procedures described by Snider et al. in J. Orn. Chem., 60, pp.5376-5377 (1995).

The modifying agents of the invention can improve physical properties of polyolefins such as polypropylene, as well as other polyolefin copolymers derived from monomers comprising at least one olefinic monomer. The polyolefins can generally have a melt flow rate in the range from about 1 to 70, preferably about 7 to 35 g/10 min according to ASTM D-1238.

Polyolefins useful in the composition of the invention include polymers and copolymers derived from one or more olefinic monomer of the general formula CH2=CHR", wherein R" is hydrogen or Cm is alkyl. Examples of such olefinic monomers include propylene, ethylene, and l-butene, with propylene being generally preferred. Representative examples of polyolefins derived from such olefinic monomers include polyethylene, polypropylene, polybutene-l, poly(3- methylbutene), poly(4-methylpentene) and copolymers of ethylene with propylene, l-butene, l-hexene, I-octene, decene-1,4-methyl-l -pentene and l-octadecene.

The polyolefin may optionally comprise a copolymer derived from an olefinic monomer and one or more further comonomers that are copolymerizable with the olefinic monomer. These comonomers can be present in the polyolefin in an amount in the range from about 1 to 10 wt-% based on the total weight of polyolefin. UsefUl such comonomers include, for example, vinyl ester monomers such as vinyl acetate, vinyl propionate, vinyl butyrate, vinyl chloroacetate, vinyl chloropropionate; acrylic and alpha-alkyl acrylic acid monomers, and their alkyl esters, amides, and nitriles such as acrylic acid, methacrylic acid, ethacrylic acid, methyl acrylate, ethyl acrylate, N,N-dimethyl acrylamide, methacrylamide, acrylonitrile; vinyl aryl monomers such as styrene, o-methoxystyrene, p-methoxystyrene, and vinyl naphthalene; vinyl and vinylidene halide monomers such as vinyl chloride, vinylidene chloride, and vinylidene bromide; alkyl ester monomers of maleic and fumaric acid such as dimethyl maleate, and diethyl maleate; vinyl alkyl ether monomers such as vinyl methyl ether, vinyl ethyl ether, vinyl isobutyl ether, and 2-chloroethyl vinyl ether; vinyl pyridine monomers; N-vinyl carbazole monomers, and N-vinyl pyrrolidine monomers.

The polyolefin may also contain a metallic salt form of a polyolefin, or a blend thereof which contains free carboxylic acid groups. Illustrative of the metals which can be used to provide the salts of said carboxylic acid polymers are the one, two and three valence metals such as sodium, lithium, potassium, calcium, magnesium, aluminum, barium, zinc, zirconium, beryllium, iron, nickel and cobalt.

Preferred polyolefins include polypropylene homopolymers and copolymers of propylene with ethylene, I-butene, I-hexene, l-octene, 4-methyl-l-pentene, vinyl acetate, or methyl acrylate.

The polyolefin can also include blends of these polyolefins with other polyolefins or copolymers or blends thereof containing conventional adjuvants such as antioxidants, light stabilizers, acid neutralizers, fillers, antiblocking agents and pigments.

Representative blends of polyolefins useful in this invention include blends of polyethylene and polypropylene, low density polyethylene and high-density polyethylene, and polyethylene and olefin copolymers derived from an olefinic

mononer and one or more of the above-described optional copolymerizable comonomers, e.g., ethylene and acrylic acid copolymers; ethylene and methyl acrylate copolymers; ethylene and ethyl acrylate copolymers; ethylene and vinyl acetate copolymers; ethylene, acrylic acid, and ethyl acrylate copolymers, and ethylene, acrylic acid, and vinyl acetate copolymers.

The modifying agent may be incorporated into a polyolefin using any method that does not cause substantial degradation or vaporization of the modifying agent. This can be accomplished using any mixing method that is convenient, such as a melt mixer, an extruder, and the like. The modifying agent may be dry blended with the polyolefin in flake, granule, or pellet form; a liquid melt, dispersion, suspension or solution of the modifying agent may be combined with the polyolefin in flake, granule, or pellet form; or a concentrated blend of the modifying agent in polyolefin may first be prepared and then blended with the polyolefin to obtain a final desired concentration of modifying agent in polyolefin. If such a concentrated blend is prepared the modifying agent can be present in the concentrated blend in an amount in the range from about 0.5 to 5 wt-%.

If desired, components may be added to the polyolefin in addition to the modifying agent. Examples of such components include pigments, antioxidants, acid neutralizers, antistatic agents, ultraviolet light absorbers, and hindered amine stabilizers.

The modifying agent can be added to the polyolefin at any time during processing of the polyolefin, so long as adequate dispersion of the modifying agent is obtained before the polyolefin begins to crystallize.

The polyolefin containing a desired amount of modifying agent can be formed into articles as desired in any manner known in the art. For example the polymer can be injection molded, extruded, thermoformed, compression molded, pressed and so on to form desired shapes and articles.

The invention is further described by reference to the following examples, which are understood to be illustrative and not limiting of the invention. Reported yields of greater than 100% of theoretical yield are believed to be caused by incomplete removal of solvent and/or absorption of water.

Examples Preparation of Additives Preparative Example 1 - Dilithium bicyclo[2.2.1]hept-5-en-2,3-dicarboxylate To a suspension of norborn-5-en-2,3-dicarboxylic acid (5.02 g, 27.6 mmol) in H20 (170 mL) was added LiOHH2O (2.57 g, 61.3 mmol) at room temperature. MeOH was added with stirring until a homogeneous solution was obtained. The solvent was removed iJ? lac?lo and the resulting colorless, crystalline product was dried.

Preparative Example 2 - 2-Methyl-3-sodium bicyclo[2.2. l]hept-5-en-2,3- dicarboxylate To a solution of norborn-5-en-2,3-dicarboxylic anhydride (5.05 g, 30.8 mmol) in MeOH (50 mL) was added pyridine (50 p1L) and the reaction mixture was heated to reflux temperature for 2 hours, with stirring. The solvent was removed iii vacua.

The resulting solid residue was dissolved in EtOAc and extracted three times with 10% NaHCO;. The aqueous layer was acidified with conc. HCl1 until the pH was 1 and extracted three times with EtOAc. The combined organic phases were washed with brine and dried over Na2SO4. Evaporation of the solvent gave a solid (5.87 g) which was recrystallized from EtOAc/hexane (1 1) to yield the product as colorless crystals: 3.37 g (56%), mp=102-103°C.

To a solution of the above product (1 .00 g, 5.1 mmol) in MeOH/ H2O ( I 1) (20 mL) was added 1N NaOH (5. 1 mL, 5.1 mmol) and the reaction mixture was stirred

at room temperature for 15 min. The solvent was removed in vaclSo and the resulting colorless powder was dried. Yield: 1.00 g (90%), mp=244°C.

Preparative Example 3 - Octadecyl bicyclo[2.2. 1] hept-5-en-3 -carboxy-2- carboxamide To a suspension of octadecylamine (3.30 g, 12.2 mmol) in CH2C12 (100 mL) was added a solution of norborn-5-en-2,3-dicarboxylic anhydride (2.01 g, 12.2 mmol) in CH2Cl2 (100 mL). The suspension was stirred at room temperature for 50 hrs.

under a N2-atmosphere. The solvent was removed in 0'acito and the resulting colorless solid was dried. Yield: 5.25 g (99%), mp=115°C.

Preparative Example 4 - Dilithium bicyclo[2.2.2joct-5-en-2,3-dicarboxylate To a solution of bicyclo[2.2.2]oct-5-en-2,3-dicarboxylic acid (1.02 g, 5.2 mmol) in EtOH (25 mL) was added a solution ofLiOHH2O (437 mg, 10.4 mmol) in H2O (25 mL). The solution was stirred at room temperature for 1 hr. The solvent was removed and the resulting colorless solid was dried.

Preparative Example 5 -2-Methyl-3-sodium bicyclo[2.2.2]oct-5-en-2,3- dicarboxylate

To a solution of bicyclo[2.2.2]oct-5-en-2,3-dicarboxylic anhydride (1 .51 g, 8.5 mmol) in MeOH (15 mL) was added pyridine (15 tL) and the solution was heated to reflux temperature for 2 hrs. The solvent was evaporated. The resulting beige syrup was dissolved in EtOAc, washed with 5% HCI, and extracted with 10% NaHCO3 (3x25 mL). The aqueous phase was acidified with conc. HCI until pH=l and extracted with EtOAc (3x30 mL). The combined organic phase was washed with brine and dried (Na2SO4). Removal ofthe solvent gave a colorless solid (1.36 g) which was recrystallized from EtOAc/hexane to yield the product as colorless crystals. Yield: 1.05 g (59%).

To a solution of the above product (746 mg, 3.6 mmol) in MeOH/H2O (2: 1) (30 mL) was added IN NaOH (3.6 mL, 3.6 mmol) and the resulting solution was stirred at room temperature for 30 min. The solvent was removed ill \?trciio and the remaining colorless solid was dried.

Preparative Example 6 - trans-bicyclo [2.2.1] hept-5-en-2,3-dicarboxylic acid To a solution of trans-norborn-5-en-2,3-dicarboxylic acid monoethyl ester, prepared from cyclopentadiene and fumaric acid monoethyl ester, (10.6 g, 50.3 mmol) in EtOH (35 mL) was added a solution of NaOH (6.2 g, 155 mmol) in H20 (30 mL) at room temperature. The reaction mixture was stirred for 2.5 hrs. at room temperature and conc. HCI was added until pH=l. The ethanol was removed in vacto and the residue extracted with 1 50 mL EtOAc. The organic phase was extracted with 10% NaHCO (3x50 mL), the aqueous phase was acidified with conc. HCI until pH=l, and extracted with EtOAc (3x50 mL). The combined organic phase was dried over Na2SO4. Removal of the solvent gave a solid (5.74 g)

which was recrystallized from EtOAc to yield the product as colorless crystals.

Yield: 3.89g(43%), mp=187°C.

Preparative Example 7 Disodium bicyclo[2.2.1]hept-5-en-2,3-dicarboxylate To a suspension of norborn-5-en-2,3-dicarboxylic acid (5.01 g, 27.5 mmole) in H2O (50 mL) was added IN aq. NaOH (55mL, 55.0 mmol) at rt and the reaction mixture was stirred until a homogeneous solution was obtained. The solvent was removed in vacuo and the resulting colorless, crystalline product was dried: 5.57 g (90%), mp=385C.

Preparative Example 8 Disodium bicyclo[2.2.1]hept-5-en-2,3-dicarboxylate To a suspension of bicyclo[2.2.2]-oct-5-en-2,3-dicarboxylic anhydride (2.01 g, 11.3 mmole) in MeOH (50mL) was added I N aq. NaOH (22.4 mL, 22.4 mmol). The reaction mixture was stirred for 1 hour at room temperature. The solvent was removed is acl/o and the resulting colorless solid was dried: mp>400C.

In the following Examples and Comparative Examples, various compositions of polyolefins and clarifying and/or nucleating additives were prepared. The compositions were evaluated by measuring crystallization properties using Differential Scanning Calorimetry (DSC) according to ASTM D-794-85, run at a rate of 20°C/min and by measuring haze using ASTM D 1003-92. All percentages given are in wt% unless othenvise stated.

Formulation Example A composition of the invention was made in a Haake Rheocord 90 melt mixer by combining 0.950 g ofthe compound ofPreparative Example I with 190 g ofQuantum1 8310 GO, available from Quantum Chemical Co, Cincinatti, OH.

The polymer was a random copolymer with 3% ethylene and contained an additive package of 300 ppm IrganoxTN' 1010 antioxidant, 500 ppm UltranoxM 626 antioxidant and 1000 ppm calcium stearate.

The composition was mixed for three minutes at 2000C and 15 rpm and for an additional five minutes at 1 700C at 50 rpm with a one minute transition period between the two sets of conditions.

The crystallization parameters of the composition were determined by DSC.

A sample was heated to 2000C, held for 10 minutes, and cooled at a rate of 20"C per minute to about 40"C. Crystallization temperature at onset and peak temperature were recorded.

To determine clarification ability of the composition, a compression molded haze plaque was prepared by heating 6.5-7 g of the composition to 200"C for three minutes on a Carver hotpress. The sample was then pressed to (10,000 psi) with a 0.5mm spacer for four minutes. The plaque was then water cooled to 20-25"C.

Percent haze was then measured on a BYK Gardener XL-2 11 Hazegard System to determine the haze.

Similar compositions were prepared from olefin and the compounds described in Table 1.

Control Example In the Control Example, a compression molded plaque was made in a manner similar to that described in the Formulation Example except that no nucleating or clarifying additive was used. The % haze of the control material was determined by preparing a plaque using a Cincinnati Milacron 50 ACT-D injection molding machine. The machine operated at 2300C and the mold was maintained at 320C. After about 30 seconds, the 1.2mm thick plaque was ejected from the mold and evaluated as above.

A variety of nucleating/clarifying agents were compounded with polyolefin and evaluated for haze and crystallinity as described in the above Formulation Example. The results are reported in Table 1.

Tnhle 1: Cyclopentadiene/Cyclohexadiene Anhydride Derived Additives as Nucleators/Clarifiers Entr Additive Additive Cryst. Temp. Cryst. Temp. % Haze Y Conc. (DSC onset) (DSC peak (%w/w) [°C] max) [°C] A none 97.1 89.8 55 For the values given above, an increased crystallization temperature indicates enhanced heterogeneous nucleation of the polymer and decreased haze values demonstrate improved clarity of the polymer.

The foregoing specification and examples provide a complete description of the invention. However, because many variations are possible without departing from the spirit and scope of the invention, the invention resides solely in the claims which follow.