Title:
MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES
Document Type and Number:
WIPO Patent Application WO/2016/077215
Kind Code:
A3
Abstract:
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.
Inventors:
MELLMAN IRA S (US)
FAHMY TAREK M (US)
SALTZMAN WILLIAM MARK (US)
CAPLAN MICHAEL J (US)
FAHMY TAREK M (US)
SALTZMAN WILLIAM MARK (US)
CAPLAN MICHAEL J (US)
Application Number:
PCT/US2015/059711
Publication Date:
June 16, 2016
Filing Date:
November 09, 2015
Export Citation:
Assignee:
UNIV YALE (US)
International Classes:
A61K39/00; A61K39/39; A61K47/48; B82Y5/00
Domestic Patent References:
| WO2008115641A2 | 2008-09-25 |
Other References:
DEMENTO S L ET AL: "Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 23, 18 May 2009 (2009-05-18), pages 3013 - 3021, XP026058717, ISSN: 0264-410X, [retrieved on 20090403], DOI: 10.1016/J.VACCINE.2009.03.034
FAHMY T M ET AL: "Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 28, 1 October 2005 (2005-10-01), pages 5727 - 5736, XP027767526, ISSN: 0142-9612, [retrieved on 20051001]
FISCHER NICHOLAS O ET AL: "Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis.", BIOCONJUGATE CHEMISTRY 16 JUN 2010, vol. 21, no. 6, 16 June 2010 (2010-06-16), pages 1018 - 1022, XP002753772, ISSN: 1520-4812
MALLAJOSYULA JYOTHI K ET AL: "Single-dose monomeric HA subunit vaccine generates full protection from influenza challenge.", HUMAN VACCINES & IMMUNOTHERAPEUTICS 2014, vol. 10, no. 3, 30 December 2013 (2013-12-30), pages 586 - 595, XP002753773, ISSN: 2164-554X
FAHMY T M ET AL: "Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 28, 1 October 2005 (2005-10-01), pages 5727 - 5736, XP027767526, ISSN: 0142-9612, [retrieved on 20051001]
FISCHER NICHOLAS O ET AL: "Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis.", BIOCONJUGATE CHEMISTRY 16 JUN 2010, vol. 21, no. 6, 16 June 2010 (2010-06-16), pages 1018 - 1022, XP002753772, ISSN: 1520-4812
MALLAJOSYULA JYOTHI K ET AL: "Single-dose monomeric HA subunit vaccine generates full protection from influenza challenge.", HUMAN VACCINES & IMMUNOTHERAPEUTICS 2014, vol. 10, no. 3, 30 December 2013 (2013-12-30), pages 586 - 595, XP002753773, ISSN: 2164-554X
Attorney, Agent or Firm:
PABST, Patrea L. et al. (1545 Peachtree Street N.E., Suite 32, Atlanta GA, US)
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