Title:
MOLECULARLY MODIFIED STRUCTURES OF GLP-1R ACTIVATORS AND USE OF DIMERS THEREOF IN TREATING METABOLIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/160185
Kind Code:
A1
Abstract:
Provided are molecularly modified structures of GLP-1R Exendin-4, GIP-Exendin-4 chimeric polypeptide, and GLP-1, said modified structures forming dimers by means of connection of disulfide bonds formed by cysteine. The modified structures can treat metabolic syndromes, including treating diabetes and obesity.
Inventors:
TANG SONGSHAN (CN)
ZHANG XUDONG (CN)
LUO QUN (CN)
YANG LI (CN)
TAN HONGMEI (CN)
TANG JINGXUAN (CN)
YOU JUAN (CN)
ZHANG XUDONG (CN)
LUO QUN (CN)
YANG LI (CN)
TAN HONGMEI (CN)
TANG JINGXUAN (CN)
YOU JUAN (CN)
Application Number:
PCT/CN2021/078057
Publication Date:
August 19, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
NANJING FINEPEPTIDE BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/605; A61K38/26; A61P3/04; A61P3/10
Foreign References:
| CN110845601A | 2020-02-28 | |||
| CN103833841A | 2014-06-04 | |||
| CN107735100A | 2018-02-23 | |||
| CN101663317A | 2010-03-03 | |||
| CN102946875A | 2013-02-27 | |||
| CN111410686A | 2020-07-14 |
Attorney, Agent or Firm:
GUANGZHOU KEYUE I.P. LAW OFFICE (CN)
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