MOUSE ANTIBODY V-REGION GENE FRAGMENT AND PREPARATION OF CHIMERA ANTIBODY BY USING SAID GENE FRAGMENT

Title:

MOUSE ANTIBODY V-REGION GENE FRAGMENT AND PREPARATION OF CHIMERA ANTIBODY BY USING SAID GENE FRAGMENT

Document Type and Number:

WIPO Patent Application WO/1991/006649

Kind Code:

A1

Abstract:

The invention relates to a V-region gene fragment of a mouse monoclonal antibody against an antigen derived from colon cancer colon 6; a plasmid on which is supported a chimera antibody gene wherein said gene fragment is ligated to a human antibody C-region gene, etc.; a host transformed by using said plasmid, and a method of preparing a chimera antiboby by culturing said host to express the chimera antibody, wherein the chimera antibody can be efficiently produced in a stable manner especially when yeast is used as the host.

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Inventors:

KANEDA TERUO (JP)
TAKESHIMA KAZUYA (JP)
GOTO TAKASHI (JP)
MIYAGI IKUKO (JP)

Application Number:

PCT/JP1990/001446

Publication Date:

May 16, 1991

Filing Date:

November 07, 1990

Export Citation:

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Assignee:

GREEN CROSS CORP (JP)

International Classes:

C07K16/30; C12N1/19; C12N15/13; C12N15/81; C12P21/08; (IPC1-7): C12N1/19; C12N15/13; C12N15/62; C12P21/08

Foreign References:

JPS63207396A

1988-08-26

Other References:

Science, Vol. 229 (1985) S.L. MORRISON (Transfectomas Provide Novel Chimeric Antibodies) p. 1202-1207.
See also references of EP 0452508A4

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