Title:
MSP-3-LIKE FAMILY OF GENES
Document Type and Number:
WIPO Patent Application WO2005040203
Kind Code:
A3
Abstract:
The present invention relates to the protection against malaria. More particularly, the invention pertains to a family of genes encompassing the already known MSP-3 gene, and showing exceptional redundancy of exposed epitopes, hence suggesting that this family of genes plays an important part in the immunogenicity of the parasite. The characterization of this gene family enables the definition of immunogenic and vaccine compositions against P. falciparum. The invention also relates to an antigenic polypeptidic composition, comprising at least one MSP-3-b-like motif and at least one MSP-3c/d-like motif.
Inventors:
DRUILHE PIERRE (FR)
SINGH SUBHASH (IN)
SOE SOE DAW (FR)
MEJIA PEDRO (FR)
SINGH SUBHASH (IN)
SOE SOE DAW (FR)
MEJIA PEDRO (FR)
Application Number:
PCT/EP2004/012909
Publication Date:
June 23, 2005
Filing Date:
October 22, 2004
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
DRUILHE PIERRE (FR)
SINGH SUBHASH (IN)
SOE SOE DAW (FR)
MEJIA PEDRO (FR)
DRUILHE PIERRE (FR)
SINGH SUBHASH (IN)
SOE SOE DAW (FR)
MEJIA PEDRO (FR)
International Classes:
C07K14/445; C12N15/30; A61K39/00; (IPC1-7): C12N15/30; C07K14/445; A61K39/015; C07K16/20; A61K39/395; G01N33/569; A61K48/00; C12N15/63
Foreign References:
| US20020076403A1 | 2002-06-20 |
Other References:
CARLOTTA TRUCCO ET AL.: "The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 112, 2001, pages 91 - 101, XP002283182
DAMIAN J. MCCOLL ET AL.: "Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3)", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 90, 1997, pages 21 - 31, XP002314475
CLAUDE OEUVRAY ET AL.: "Merozoite surface protein - 3: A malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes", BLOOD, vol. 84, no. 5, 1 September 1994 (1994-09-01), pages 1594 - 1602, XP000008820
MICHAEL THEISEN ET AL.: "Identification of a major B-cell epitope of the Plasmodium falciparum glutamate-rich protein (GLURP), targeted by human antibodies mediating parasite killing", VACCINE, vol. 19, 2001, pages 204 - 212, XP004228829
VIKKI M. MARSHALL ET AL.: "Close linkage of three merozoite surface protein genes on chromosome 2 of Plasmodium falciparum", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, no. 94, 1998, pages 13 - 25, XP002283184
DAMIAN J. MCCOLL ET AL.: "Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3)", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 90, 1997, pages 21 - 31, XP002314475
CLAUDE OEUVRAY ET AL.: "Merozoite surface protein - 3: A malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes", BLOOD, vol. 84, no. 5, 1 September 1994 (1994-09-01), pages 1594 - 1602, XP000008820
MICHAEL THEISEN ET AL.: "Identification of a major B-cell epitope of the Plasmodium falciparum glutamate-rich protein (GLURP), targeted by human antibodies mediating parasite killing", VACCINE, vol. 19, 2001, pages 204 - 212, XP004228829
VIKKI M. MARSHALL ET AL.: "Close linkage of three merozoite surface protein genes on chromosome 2 of Plasmodium falciparum", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, no. 94, 1998, pages 13 - 25, XP002283184
Download PDF:
Previous Patent: STABILIZED ALPHA-HELICAL PEPTIDES
Next Patent: GLURP-MSP3 FUSION PROTEIN, IMMUNOGENIC COMPOSITIONS AND MALARIAL VACCINES CONTAINING IT
Next Patent: GLURP-MSP3 FUSION PROTEIN, IMMUNOGENIC COMPOSITIONS AND MALARIAL VACCINES CONTAINING IT