MUCOSAL DELIVERY COMPOSITIONS COMPRISING A PEPTIDE COMPLEXED WITH A CROWN COMPPOUND AND/OR A COUNTER ION

Title:

MUCOSAL DELIVERY COMPOSITIONS COMPRISING A PEPTIDE COMPLEXED WITH A CROWN COMPPOUND AND/OR A COUNTER ION

Document Type and Number:

WIPO Patent Application WO/2011/064316

Kind Code:

A3

Abstract:

Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a nonaqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.

Inventors:

BOTTI PAOLO (CH)
TCHERTCHIAN SYLVIE (FR)

Application Number:

PCT/EP2010/068257

Publication Date:

January 05, 2012

Filing Date:

November 25, 2010

Export Citation:

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Assignee:

BOTTI PAOLO (CH)
TCHERTCHIAN SYLVIE (FR)

International Classes:

A61K38/00; A61K9/00; A61K9/12; A61K38/26; A61K47/22; A61K47/48

Foreign References:

US20030171259A1	2003-09-11
EP1972332A1	2008-09-24
EP1338272A1	2003-08-27
EP0136728A2	1985-04-10

Other References: