Title:
MULTIMERIC T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/139896
Kind Code:
A1
Abstract:
The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co-immunomodulatory polypeptide. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.
Inventors:
SEIDEL III RONALD D (US)
CHAPARRO RODOLFO J (US)
CHAPARRO RODOLFO J (US)
Application Number:
PCT/US2019/012688
Publication Date:
July 18, 2019
Filing Date:
January 08, 2019
Export Citation:
Assignee:
CUE BIOPHARMA INC (US)
International Classes:
C07K14/005; A61K39/00; A61K48/00; C07K14/705
Domestic Patent References:
| WO2017201210A1 | 2017-11-23 | |||
| WO2009023270A2 | 2009-02-19 | |||
| WO2010091122A1 | 2010-08-12 | |||
| WO2007103515A2 | 2007-09-13 | |||
| WO1994012649A2 | 1994-06-09 | |||
| WO1993003769A1 | 1993-03-04 | |||
| WO1993019191A1 | 1993-09-30 | |||
| WO1994028938A1 | 1994-12-22 | |||
| WO1995011984A2 | 1995-05-04 | |||
| WO1995000655A1 | 1995-01-05 | |||
| WO1993009239A1 | 1993-05-13 |
Foreign References:
| US6322789B1 | 2001-11-27 | |||
| US6322789B1 | 2001-11-27 | |||
| US20100189682A1 | 2010-07-29 | |||
| US20090092582A1 | 2009-04-09 | |||
| US7078387B1 | 2006-07-18 | |||
| US4235871A | 1980-11-25 | |||
| US4501728A | 1985-02-26 | |||
| US4837028A | 1989-06-06 | |||
| US6287860B1 | 2001-09-11 |
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SAKAMOTO ET AL., H GENE THER, vol. 5, 1999, pages 1088 1097
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JOMARY ET AL., GENE THER, vol. 4, 1997, pages 683 690
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MENDELSON ET AL., VIROL, vol. 166, 1988, pages 154 - 165
FLOTTE ET AL., PNAS, vol. 90, 1993, pages 10613 - 10617
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See also references of EP 3737689A4
BROMLEY ET AL., ANNU REV IMMUNOL., vol. 19, 2001, pages 375 - 96
LAD ET AL., J. BIOMOL. SCREEN., vol. 20, no. 4, 2015, pages 498 - 507
SHAHDUNCAN, J. VIS. EXP., vol. 18, 2014, pages e51383
PARHAM ET AL., J. IMMUNOL., vol. 123, 1979, pages 342
ABDICHE ET AL., J. ANAL. BIOCHEM., vol. 377, 2008, pages 209
"NCBI", Database accession no. NP_001229687.1
"GenBank", Database accession no. NP_001229971.1
HASSOUNEH ET AL., METHODS ENZYMOL., vol. 502, 2012, pages 215
VALLUZZI ET AL., PHILOS TRANS R SOC LOND B BIOL SCI., vol. 357, 2002, pages 165
MEGEED ET AL., ADV DRUG DELIV REV., vol. 54, 2002, pages 1075
SCHELLENBERGER ET AL., NAT BIOTECHNOL., vol. 27, 2009, pages 1186
SCHERAGA, REV. COMPUTATIONAL CHEM., 1992, pages 11173 - 142
LI ET AL., INVEST OPTHALMOL VIS SCI, vol. 35, 1994, pages 2543 2549
BORRAS ET AL., GENE THER, vol. 6, 1999, pages 515 524
LIDAVIDSON, PNAS, vol. 92, 1995, pages 7700 7704
SAKAMOTO ET AL., H GENE THER, vol. 5, 1999, pages 1088 1097
ALI ET AL., HUM GENE THER, vol. 9, 1998, pages 81 86
FLANNERY ET AL., PNAS, vol. 94, 1997, pages 6916 6921
BENNETT ET AL., INVEST OPTHALMOL VIS SCI, vol. 38, 1997, pages 2857 2863
JOMARY ET AL., GENE THER, vol. 4, 1997, pages 683 690
ROLLING ET AL., HUM GENE THER, vol. 10, 1999, pages 641 648
ALI ET AL., HUM MOL GENET, vol. 5, 1996, pages 591 594
SAMULSKI ET AL., J. VIR., vol. 63, 1989, pages 3822 - 3828
MENDELSON ET AL., VIROL, vol. 166, 1988, pages 154 - 165
FLOTTE ET AL., PNAS, vol. 90, 1993, pages 10613 - 10617
TAKAHASHI ET AL., J VIROL, vol. 73, 1999, pages 7812 7816
BITTER ET AL., METHODS IN ENZYMOLOGY, vol. 153, 1987, pages 516 - 544
A. GENNARO: "Remington: The Science and Practice of Pharmacy", 2000, LIPPINCOTT, WILLIAMS, & WILKINS
"Pharmaceutical Dosage Forms and Drug Delivery Systems", 1999, LIPPINCOTT, WILLIAMS, & WILKINS
SZOKA ET AL., ANN. REV. BIOPHYS. BIOENG., vol. 9, 1980, pages 467
See also references of EP 3737689A4
Attorney, Agent or Firm:
BORDEN, Paula A. (US)
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