Title:
MULTIPOTENT STEM CELL HAVING ANTI-VEGF FUNCTION AND DIFFERENTIATED CELL THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/199951
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a multipotent stem cell imparted with a new function, and a differentiated cell (particularly, an endothelial cell) thereof. The present invention provides a multipotent stem cell having an anti-VEGF function or a corneal endothelial cell derived from a multipotent stem cell having an anti-VEGF function. Said cell is useful in the treatment of various diseases.
Inventors:
OKA MASAKO (JP)
HATOU SHIN (JP)
SAYANO TOMOKO (JP)
YOSHIZAKI SHINJI (JP)
HATOU SHIN (JP)
SAYANO TOMOKO (JP)
YOSHIZAKI SHINJI (JP)
Application Number:
PCT/JP2023/014910
Publication Date:
October 19, 2023
Filing Date:
April 12, 2023
Export Citation:
Assignee:
CELLUSION INC (JP)
International Classes:
C12N15/12; A61K35/44; A61K35/545; A61P27/02; A61P35/00; C12N5/10; C12N15/13
Domestic Patent References:
| WO2019098264A1 | 2019-05-23 | |||
| WO2019142833A1 | 2019-07-25 |
Foreign References:
| JP2017023130A | 2017-02-02 | |||
| JP2016513669A | 2016-05-16 | |||
| JP2010518871A | 2010-06-03 | |||
| JP2011505135A | 2011-02-24 | |||
| JP2011502503A | 2011-01-27 |
Other References:
HU M; YANG J-L; TENG H; JIA Y-Q; WANG R; ZHANG X-W; WU Y; LUO Y; CHEN X-C; ZHANG R; TIAN L; ZHAO X; WEI Y-Q: "Anti-angiogenesis therapy based on the bone marrow-derived stromal cells genetically engineered to express sFlt-1 in mouse tumor model", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 1, 23 October 2008 (2008-10-23), LONDON, GB , pages 306, XP021042944, ISSN: 1471-2407, DOI: 10.1186/1471-2407-8-306
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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