Title:
MYRISTOYLATED POLYPETIDE ENCODING MITOCHONDRIAL LOCALIZATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/246934
Kind Code:
A1
Abstract:
Provided are a myristoylated polypeptide encoding mitochondrial localization, and a preparation method therefor and the use thereof, belonging to the technical field of molecular genetics.
The polypeptide sequence has an amino acid sequence as represented by formula M-N, wherein M is an amino acid sequence as shown in SEQ ID NO: 1 and N is an amino acid sequence as shown in SEQ ID NO: 2. Further provided is the use of a polypeptide comprising a sequence as shown in SEQ ID NO: 3, a polypeptide composition, a nucleic acid and a polypeptide conjugate in the expression of a myristoylated mitochondrial localization protein. The amino terminus of the sequence contains a myristoylated conservative sequence, which can be myristoylated and then inserted into a mitochondrial cell membrane.
More Like This:
Inventors:
ZHOU LIANG (CN)
Application Number:
PCT/CN2021/101154
Publication Date:
December 01, 2022
Filing Date:
June 21, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07K19/00; C12Q1/02
Domestic Patent References:
| WO2020191361A2 | 2020-09-24 |
Foreign References:
| CN112899307A | 2021-06-04 | |||
| CN109996539A | 2019-07-09 |
Other References:
DATABASE PROTEIN 22 March 2015 (2015-03-22), ANONYMOUS : "Glutamate [NMDA] receptor subunit zeta-1 [Myotis brandtii]", XP093007337, retrieved from NCBI Database accession no. EPQ17422.1
AICH ABHISHEK, SHAHA CHANDRIMA: "Novel Role of Calmodulin in Regulating Protein Transport to Mitochondria in a Unicellular Eukaryote", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 33, no. 22, 15 November 2013 (2013-11-15), US , pages 4579 - 4593, XP093007338, ISSN: 0270-7306, DOI: 10.1128/MCB.00829-13
XU ZHENGPING, LI BOLIANG: "Myristoylation of Protein", PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, vol. 25, no. 1, 31 December 1998 (1998-12-31), XP093007245
AICH ABHISHEK, SHAHA CHANDRIMA: "Novel Role of Calmodulin in Regulating Protein Transport to Mitochondria in a Unicellular Eukaryote", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 33, no. 22, 15 November 2013 (2013-11-15), US , pages 4579 - 4593, XP093007338, ISSN: 0270-7306, DOI: 10.1128/MCB.00829-13
XU ZHENGPING, LI BOLIANG: "Myristoylation of Protein", PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, vol. 25, no. 1, 31 December 1998 (1998-12-31), XP093007245
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
Download PDF: