NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

Title:

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/215485

Kind Code:

A1

Abstract:

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

Inventors:

DUAN WENHU (CN)
GENG MEIYU (CN)
WANG YUMING (CN)
AI JING (CN)
FAN JUN (CN)
DAI YANG (CN)
DING JIAN (CN)

Application Number:

PCT/CN2017/087222

Publication Date:

December 21, 2017

Filing Date:

June 05, 2017

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

C07D487/04; A61K31/519; A61K31/5377; A61P35/00

Domestic Patent References:

WO2000017202A1	2000-03-30
WO2001072751A1	2001-10-04
WO2002076986A1	2002-10-03
WO2013087578A1	2013-06-20
WO2005047289A1	2005-05-26
WO2013070976A1	2013-05-16

Other References: