NEW DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINNEW DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS EDICAMENTS CONTAINING THESE COMPOUNDS

Title:

Document Type and Number:

WIPO Patent Application WO1996024581

Kind Code:

A3

Abstract:

Compounds of formula (I), in which R<1> stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono-or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted aryl alkyl or one of the groups -OR<2>, -NR<3>R<4>, W stands for nitrogen or -CR<5>, X, Z independently of each other stands for nitrogen or -CH, and where W stands for a nitrogen atom, X must be the group -CH, A stands for a valency bond or the carbonyl group, B stands for a valency bond or a C1-C6 alkyl chain possibly substituted once or several times by lower alkyl or an OR<2> group, D stands for a valency bond, and, where X is a nitrogen atom, can also be the carbonyl group, A, B and D being unable to represent the valency bond simultaneously, R<2> stands for hydrogen, lower alkyl or aryl alkyl, R<3>, R<4> independently of each other stand for hydrogen or lower alkyl, or form a five- or six-membered heterocyclic ring together with the nitrogen atom to which they are linked, R<5> stands for hydrogen or a group OR<2>. The invention also relates to a process for the production of these compounds, and medicaments containing them for the treatment of diseases which are attributable to thromboembolic conditions.

Inventors:

TSAKLAKIDIS CHRISTOS (DE)
MERTENS ALFRED (DE)
ZIMMERMANN GERD (DE)
SCHAEFER WOLFGANG (DE)
DOERGE LIESEL (DE)

Application Number:

PCT/EP1996/000524

Publication Date:

November 28, 1996

Filing Date:

February 08, 1996

Export Citation:

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Assignee:

BOEHRINGER MANNHEIM GMBH (DE)
TSAKLAKIDIS CHRISTOS (DE)
MERTENS ALFRED (DE)
ZIMMERMANN GERD (DE)
SCHAEFER WOLFGANG (DE)
DOERGE LIESEL (DE)

International Classes:

A61K31/495; A61K31/50; C07D237/20; A61P7/02; C07D213/74; (IPC1-7): C07D/; A61K/

Domestic Patent References:

WO1994022835A2

1994-10-13

Foreign References:

EP0718287A2

1996-06-26

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