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Title:
NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES
Document Type and Number:
WIPO Patent Application WO/2008/129994
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a compound useful as a prophylactic or therapeutic agent for a sex hormone-dependent disease or the like. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a nitrogenated fused ring derivative represented by the general formula (I), or a prodrug, salt or the like thereof, which has a GnRH antagonistic activity; a pharmaceutical composition comprising the derivative or the prodrug, salt or the like thereof; use of the the derivative or the prodrug, salt or the like thereof for medical purposes; and others. In the general formula (I), the rings A and B independently represent an aryl or a heteroaryl; RA and RB independently represent a halogen, a cyano, an alkyl, an alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, an aryl or the like; RC represents H or an alkyl; E represents an oxygen atom or the like; U represetns a single bond or an alkylene; and X represents Y, -CO-Y, -SO2-Y, -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y or the like [wherein Y represents Z, an amino or the like; and Z represents a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl or the like].

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Inventors:
YONEKUBO SHIGERU (JP)
MIYAGI TAKASHI (JP)
OHNO KOHSUKE (JP)
KAMBARA MIKIE (JP)
FUSHIMI NOBUHIKO (JP)
Application Number:
PCT/JP2008/057390
Publication Date:
October 30, 2008
Filing Date:
April 16, 2008
Export Citation:
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Assignee:
KISSEI PHARMACEUTICAL (JP)
YONEKUBO SHIGERU (JP)
MIYAGI TAKASHI (JP)
OHNO KOHSUKE (JP)
KAMBARA MIKIE (JP)
FUSHIMI NOBUHIKO (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/52; A61P1/00; A61P5/10; A61P5/24; A61P13/08; A61P15/00; A61P15/08; A61P15/16; A61P15/18; A61P17/00; A61P17/02; A61P17/10; A61P17/14; A61P25/20; A61P25/28; A61P35/00; A61P37/08; A61P43/00; C07D473/00; C07D473/26; C07D473/28; C07D473/30; C07D473/32
Domestic Patent References:
WO1999057103A11999-11-11
WO2006036883A22006-04-06
WO2007034817A12007-03-29
WO2006049890A12006-05-11
WO2006009734A12006-01-26
WO2006010594A12006-02-02
WO2005035498A12005-04-21
Foreign References:
JPH04305568A1992-10-28
JPS51143696A1976-12-10
JPH11292720A1999-10-26
JP2003511378A2003-03-25
JPH1059942A1998-03-03
Other References:
SMALLHEER J.M. ET AL.: "SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 21, 2004, pages 5263 - 5267, XP004580511
CLARK R.L. ET AL.: "Synthesis and Analgesic Activity of 1,3-Dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(Substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 21, no. 9, 1978, pages 965 - 978, XP001191133
See also references of EP 2143724A4
HYOJUN SEIRIGAKU: "Standard Physiology", pages: 882 - 891
SANKA TO FUJINKA, OBSTETRICS AND GYNECOLOGY, vol. 71, no. 3, 2004, pages 280 - 285
MARIO BIANCH: "Chimica Therapeitica", EUR. J. MED. CHEM, vol. 16, no. 4, 1981, pages 321 - 326
V.K.AGRAWAL, INDIAN JOURNAL OF CHEMISTRY, vol. 20, May 1981 (1981-05-01), pages 398 - 400
IYAKUHIN NO KAIHATSU, vol. 7, pages 163 - 198
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