Title:
NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE
Document Type and Number:
WIPO Patent Application WO/2011/136292
Kind Code:
A1
Abstract:
Provided is a novel low molecular weight compound which inhibits the production of inducible MMPs, in particular MMP-9, rather than the production of constitutive MMP-2. Also provided is a prophylactic and/or therapeutic agent for an autoimmune disease or arthrosis deformans. An amide derivative represented by formula (I) [wherein each symbol is as defined in the specification], or a pharmacologically acceptable salt thereof.
Inventors:
MAEDA KAZUHIRO (JP)
ENDOH JUN-ICHI (JP)
TARAO AKIKO (JP)
TASHIRO KAORU (JP)
ISHIBUCHI SEIGO (JP)
HIKAWA HIDEMASA (JP)
ENDOH JUN-ICHI (JP)
TARAO AKIKO (JP)
TASHIRO KAORU (JP)
ISHIBUCHI SEIGO (JP)
HIKAWA HIDEMASA (JP)
Application Number:
PCT/JP2011/060307
Publication Date:
November 03, 2011
Filing Date:
April 27, 2011
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
MAEDA KAZUHIRO (JP)
ENDOH JUN-ICHI (JP)
TARAO AKIKO (JP)
TASHIRO KAORU (JP)
ISHIBUCHI SEIGO (JP)
HIKAWA HIDEMASA (JP)
MAEDA KAZUHIRO (JP)
ENDOH JUN-ICHI (JP)
TARAO AKIKO (JP)
TASHIRO KAORU (JP)
ISHIBUCHI SEIGO (JP)
HIKAWA HIDEMASA (JP)
International Classes:
C07D211/32; A61K31/437; A61K31/445; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61P1/04; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P37/00; A61P43/00; C07D205/08; C07D207/27; C07D207/273; C07D207/277; C07D209/54; C07D211/76; C07D213/74; C07D275/02; C07D295/18; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D413/12; C07D413/14; C07D417/04; C07D417/10; C07D417/12; C07D417/14; C07D471/04; C07D471/08
Domestic Patent References:
| WO2005023260A1 | 2005-03-17 | |||
| WO2009138438A1 | 2009-11-19 | |||
| WO2007129646A1 | 2007-11-15 | |||
| WO2005077912A1 | 2005-08-25 | |||
| WO2010050461A1 | 2010-05-06 |
Foreign References:
| JP2004359657A | 2004-12-24 |
Other References:
PINARD E. ET AL.: "Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 18, 2008, pages 5134 - 5139, XP025407689
DATABASE REGISTRY [online] 29 April 2008 (2008-04-29), "Methanesulfonamide, N-[4-[[4-(2,4-dimethylphenyl)-1-piperazinyl]carbonyl]phenyl]", XP003031727, accession no. STN Database accession no. 1018135-60-8
DATABASE REGISTRY [online] 9 August 2006 (2006-08-09), "Methanone, [4-(2,4-dimethylphenyl)-1-piperazinyl] [4-(1,1-dioxido-2-isothiazolidinyl)phenyl-", XP003031728, accession no. STN Database accession no. 899965-48-1
CHENG X. ET AL.: "Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 8, 2009, pages 3018 - 3024, XP026035367
ANN. RHEUM. DIS., vol. 58, 1999, pages 691 - 697
J. CLIN. INVEST., vol. 92, 1993, pages 179 - 185
ARTHRITIS RHEUM., vol. 46, 2002, pages 2625 - 2631
LANCET NEUROL., vol. 2, 2003, pages 747 - 756
ARTHRITIS RHEUM., vol. 50, 2004, pages 858 - 865
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 79, 2006, pages 954 - 962
J. NATL. CANCER INST., vol. 94, 2002, pages 1134 - 1142
J. IMMUNOL., vol. 169, 2002, pages 2643 - 2647
SCIENCE, vol. 289, 2000, pages 1202 - 1206
DATABASE REGISTRY [online] 29 April 2008 (2008-04-29), "Methanesulfonamide, N-[4-[[4-(2,4-dimethylphenyl)-1-piperazinyl]carbonyl]phenyl]", XP003031727, accession no. STN Database accession no. 1018135-60-8
DATABASE REGISTRY [online] 9 August 2006 (2006-08-09), "Methanone, [4-(2,4-dimethylphenyl)-1-piperazinyl] [4-(1,1-dioxido-2-isothiazolidinyl)phenyl-", XP003031728, accession no. STN Database accession no. 899965-48-1
CHENG X. ET AL.: "Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 8, 2009, pages 3018 - 3024, XP026035367
ANN. RHEUM. DIS., vol. 58, 1999, pages 691 - 697
J. CLIN. INVEST., vol. 92, 1993, pages 179 - 185
ARTHRITIS RHEUM., vol. 46, 2002, pages 2625 - 2631
LANCET NEUROL., vol. 2, 2003, pages 747 - 756
ARTHRITIS RHEUM., vol. 50, 2004, pages 858 - 865
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 79, 2006, pages 954 - 962
J. NATL. CANCER INST., vol. 94, 2002, pages 1134 - 1142
J. IMMUNOL., vol. 169, 2002, pages 2643 - 2647
SCIENCE, vol. 289, 2000, pages 1202 - 1206
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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