NOVEL AMINO ACID AND PEPTIDE INHIBITORS OF STAPHYLOCOCCUS VIRULENCE

Title:

NOVEL AMINO ACID AND PEPTIDE INHIBITORS OF STAPHYLOCOCCUS VIRULENCE

Document Type and Number:

WIPO Patent Application WO2001058471

Kind Code:

A3

Abstract:

Isolated synthetic modified amino acids and peptides, which inhibit the production of virulence factors in bacteria, particularly Staphylococcus, are described. The amino acids and peptides can be used in a method for treatment or prevention of Staphylococcal infections or can be integrated into a medical device to inhibit the development of infection associated with the use of such devices.

Inventors:

WRIGHT SUSAN C
LARRICK JAMES W
WANG YUQIANG
EMLEN J WOODRUFF
VAN VLASSELAER PETER
SPACK EDWARD G

Application Number:

PCT/US2001/004288

Publication Date:

March 07, 2002

Filing Date:

February 09, 2001

Export Citation:

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Assignee:

INTERMUNE INC (US)

International Classes:

A61K31/195; A61K31/198; A61K31/401; A61K31/405; A61K31/43; A61K31/472; A61K38/07; A61K38/08; A61K38/00; A61K38/14; A61P31/04; A61P43/00; C07D209/20; C07K5/087; C07K7/06; (IPC1-7): A61K38/08; A61K38/07; A61K31/198; A61K31/405; A61P31/04; A61K45/06; A61K31/195; C07C229/00

Domestic Patent References:

WO1999032133A1	1999-07-01
WO1996010579A1	1996-04-11
WO1998032133A1	1998-07-23
WO1997044349A1	1997-11-27
WO2000015660A1	2000-03-23

Foreign References:

EP0516070A1

1992-12-02

Other References:

PATENT ABSTRACTS OF JAPAN vol. 1995, no. 02 31 March 1995 (1995-03-31)
HAMURO Y ET AL: "DE NOVO DESIGN OF ANTIBACTERIAL BETA-PEPTIDES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 121, no. 51, 1999, pages 12200 - 12201, XP000999381, ISSN: 0002-7863

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