Title:
NOVEL ANTIBODY SPECIFIC FOR CLEC14A AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/187724
Kind Code:
A1
Abstract:
The present invention relates to a novel antibody specifically binding to the clec14a (C-type lectin domain family 14, member A) and uses thereof. More particularly, the present invention relates to an antibody specifically binding to the CTLD (C-type lectin like domain) of clec14a, a method for preparing the antibody, a composition for the suppression of angiogenesis, comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition for preventing or treating cancer, comprising the antibody, a method for treating cancer by administering the antibody or the composition, a composition for diagnosing cancer, comprising the antibody, a kit for diagnosing cancer comprising the compostion, a method for diagnosing cancer using the composition, a composition for the suppression of angiogenesis, comprising a material for inhibiting expression of clec14a, a kit for angiogenesis, comprising the composition, a method for suppressing angiogenesis or treating cancer, using the compostion, and the use of the CTLD of clec14a as an epitope for an antibody suppressive of angiogenesis. The antibody can effectively inhibit cle14a-mediated cancer progression.
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Inventors:
LEE SUK MOOK (KR)
KI MIN KYOUNG (KR)
JEOUNG MEE HYUN (KR)
CHOI JONG RIP (KR)
KI MIN KYOUNG (KR)
JEOUNG MEE HYUN (KR)
CHOI JONG RIP (KR)
Application Number:
PCT/KR2013/005272
Publication Date:
December 19, 2013
Filing Date:
June 14, 2013
Export Citation:
Assignee:
SCRIPPS KOREA ANTIBODY INST (KR)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13
Domestic Patent References:
| WO2011027132A1 | 2011-03-10 | |||
| WO2011119980A1 | 2011-09-29 | |||
| WO2011027132A1 | 2011-03-10 |
Foreign References:
| US5660985A | 1997-08-26 | |||
| US5756703A |
Other References:
MURA, M. ET AL.: "Identification and angiogenic role of the novel tumor endothelial marker CLEC14A", ONCOGENE, vol. 31, no. 3, 27 June 2011 (2011-06-27), pages 293 - 305, XP055177748
RHO, SEUNG-SIK ET AL.: "Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 404, no. 1, 21 November 2010 (2010-11-21), pages 103 - 108, XP027586993
ZELENSKY, ALEX N. ET AL.: "The C-type lectin-like domain superfamily", THE FEBS JOURNAL, vol. 272, no. 24, December 2005 (2005-12-01), pages 6179 - 6217, XP009111435
DATABASE GENBANK [online] 14 November 2006 (2006-11-14), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034225, Database accession no. CAL05539.1
DATABASE GENBANK [online] 1 July 2001 (2001-07-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034226, Database accession no. CAC43215.1
DATABASE GENBANK [online] 1 June 2004 (2004-06-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034227, Database accession no. CAE45477.1
DATABASE GENBANK [online] 28 August 2007 (2007-08-28), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034228, Database accession no. ABI50652.1
DATABASE GENBANK [online] 1 April 2007 (2007-04-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION PROTEIN, PARTIAL [HOMO SAPIENS]", XP003034229, Database accession no. AAT84384.1
DATABASE GENBANK [online] 11 January 2012 (2012-01-11), XP003034230, Database accession no. JN577822.1
DATABASE GENBANK [online] 12 August 2008 (2008-08-12), "TRICHOPLAX ADHAERENS HYPOTHETICAL PROTEIN, MRNA", XP003034231, Database accession no. XM_002115467.1
DATABASE GENBANK [online] 24 May 2004 (2004-05-24), "HOMO SAPIENS CLONE 011.13A9H IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION MRNA,PARTIAL CDS", XP003034232, Database accession no. AY423191.1
KI, M-K ET AL.: "Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro", ONCOGENE, 6 May 2013 (2013-05-06), XP055177751
SMITH GP: "Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface", SCIENCE, vol. 228, no. 4705, 1985, pages 1315 - 1317, XP002464311, DOI: doi:10.1126/science.4001944
SMITH GP; PETRENKO VA: "Phage display", CHEM. REV., vol. 97, no. 2, 1997, pages 391 - 410, XP000683275, DOI: doi:10.1021/cr960065d
See also references of EP 2861623A4
RHO, SEUNG-SIK ET AL.: "Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 404, no. 1, 21 November 2010 (2010-11-21), pages 103 - 108, XP027586993
ZELENSKY, ALEX N. ET AL.: "The C-type lectin-like domain superfamily", THE FEBS JOURNAL, vol. 272, no. 24, December 2005 (2005-12-01), pages 6179 - 6217, XP009111435
DATABASE GENBANK [online] 14 November 2006 (2006-11-14), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034225, Database accession no. CAL05539.1
DATABASE GENBANK [online] 1 July 2001 (2001-07-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034226, Database accession no. CAC43215.1
DATABASE GENBANK [online] 1 June 2004 (2004-06-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034227, Database accession no. CAE45477.1
DATABASE GENBANK [online] 28 August 2007 (2007-08-28), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION, PARTIAL [HOMO SAPIENS]", XP003034228, Database accession no. ABI50652.1
DATABASE GENBANK [online] 1 April 2007 (2007-04-01), "IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION PROTEIN, PARTIAL [HOMO SAPIENS]", XP003034229, Database accession no. AAT84384.1
DATABASE GENBANK [online] 11 January 2012 (2012-01-11), XP003034230, Database accession no. JN577822.1
DATABASE GENBANK [online] 12 August 2008 (2008-08-12), "TRICHOPLAX ADHAERENS HYPOTHETICAL PROTEIN, MRNA", XP003034231, Database accession no. XM_002115467.1
DATABASE GENBANK [online] 24 May 2004 (2004-05-24), "HOMO SAPIENS CLONE 011.13A9H IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION MRNA,PARTIAL CDS", XP003034232, Database accession no. AY423191.1
KI, M-K ET AL.: "Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro", ONCOGENE, 6 May 2013 (2013-05-06), XP055177751
SMITH GP: "Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface", SCIENCE, vol. 228, no. 4705, 1985, pages 1315 - 1317, XP002464311, DOI: doi:10.1126/science.4001944
SMITH GP; PETRENKO VA: "Phage display", CHEM. REV., vol. 97, no. 2, 1997, pages 391 - 410, XP000683275, DOI: doi:10.1021/cr960065d
See also references of EP 2861623A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (Yeosam Bldg.648-23, Yeoksam-dong,Gangnam-gu, Seoul 135-080, KR)
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