NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS

Title:

Document Type and Number:

WIPO Patent Application WO/2012/021013

Kind Code:

A2

Abstract:

The present invention aims to provide a novel biphenyl compound or a pharmaceutically acceptable salt thereof, a method for preparing the novel biphenyl compound or pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating diabetes complications. The novel biphenyl compound, according to the present invention, effectively suppresses generation activity of an advanced glycation end product, which causes diabetes complications and is a criterion for evaluating the effectiveness of a treating agent for diabetes complications, and shows effective treatment of retinal veins on the retina subject to diabetic retinopathy, increased occluding, and decreased angiogenesis growth factors, thereby rendering the novel biphenyl compound invention useful as an active ingredient in a composition for preventing or treating diabetes complications such as diabetic retinopathy.

Inventors:

KIM JIN SOOK (KR)
KIM YOUNG SOOK (KR)
KIM JUNG HYUN (KR)
SHON EUN JIN (KR)
KIM KI MO (KR)
KIM CHAN-SIK (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
JO KYU HYUNG (KR)
KIM OHN SOON (KR)
YOO NAM-HEE (KR)

Application Number:

PCT/KR2011/005913

Publication Date:

February 16, 2012

Filing Date:

August 11, 2011

Export Citation:

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Assignee:

KOREA INST ORIENTAL MEDICINE (KR)
KIM JIN SOOK (KR)
KIM YOUNG SOOK (KR)
KIM JUNG HYUN (KR)
SHON EUN JIN (KR)
KIM KI MO (KR)
KIM CHAN-SIK (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
JO KYU HYUNG (KR)
KIM OHN SOON (KR)
YOO NAM-HEE (KR)

International Classes:

C07C43/23; A23L33/00; A61K36/73; A61P3/10; C07C33/26

Other References:

JOURNAL OF AMERICAN MEDICAL ASSOCIATION, 2009
KLEIN R., ANNU. REV. PUBLIC. HEALTH., vol. 66, 1996, pages 366 - 78
SHARKEY T.P., J. AM. DIET. ASS., vol. 58, 1971, pages 528
VINSON, J. A. ET AL., J. NUTRITIONAL BIOCHEMISTRY, vol. 7, 1996, pages 559 - 663
SMITH, P. R. ET AL., EUR. J. BIOCHEM., vol. 210, 1992, pages 729 - 739
BROWNLEE, M. ET AL., SCIENCES, vol. 232, 1986, pages 1629 - 1632
BROWNLEE, M. ET AL., N. ENGL. MED., vol. 318, 1988, pages 1315 - 1321
BROWNLEE, M. ET AL., SCIENCE, vol. 232, 1986, pages 1629 - 1632
EDELSTEIN, D. ET AL., DIABETES, vol. 41, 1992, pages 26 - 29
AIELLO L.P., DIABETES CARE., vol. 21, pages 143 - 156
WANG. W., AM. J. PHYSIOL. HEART. CIRC. PHYSIOL., vol. 280, 2001, pages 434 - 40
SUTTER F.K., OPHTHALMOLOGY, vol. 111, 2004, pages 2044 - 9
AVERY R.L., OPHTHALMOLOGY, vol. 113, 2006, pages 363 - 72
TOKUDA H. ET AL.: "Book of Abstract of 53rd GA Congress joint with SIF", 2005
VINSON, J.A. ET AL., J. NUTR. BIOCHEM., vol. 7, 1996, pages 659 - 663
See also references of EP 2617702A4

Attorney, Agent or Firm:

LEE, Won-Hee (642-16 Yoksam-dongKangnam-ku, Seoul 135-080, KR)

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