NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS

Title:

Document Type and Number:

WIPO Patent Application WO/2012/021013

Kind Code:

A3

Abstract:

The present invention aims to provide a novel biphenyl compound or a pharmaceutically acceptable salt thereof, a method for preparing the novel biphenyl compound or pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating diabetes complications. The novel biphenyl compound, according to the present invention, effectively suppresses generation activity of an advanced glycation end product, which causes diabetes complications and is a criterion for evaluating the effectiveness of a treating agent for diabetes complications, and shows effective treatment of retinal veins on the retina subject to diabetic retinopathy, increased occluding, and decreased angiogenesis growth factors, thereby rendering the novel biphenyl compound invention useful as an active ingredient in a composition for preventing or treating diabetes complications such as diabetic retinopathy.

Inventors:

KIM JIN SOOK (KR)
KIM YOUNG SOOK (KR)
KIM JUNG HYUN (KR)
SHON EUN JIN (KR)
KIM KI MO (KR)
KIM CHAN-SIK (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
JO KYU HYUNG (KR)
KIM OHN SOON (KR)
YOO NAM-HEE (KR)

Application Number:

PCT/KR2011/005913

Publication Date:

April 19, 2012

Filing Date:

August 11, 2011

Export Citation:

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Assignee:

KOREA INST ORIENTAL MEDICINE (KR)
KIM JIN SOOK (KR)
KIM YOUNG SOOK (KR)
KIM JUNG HYUN (KR)
SHON EUN JIN (KR)
KIM KI MO (KR)
KIM CHAN-SIK (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
JO KYU HYUNG (KR)
KIM OHN SOON (KR)
YOO NAM-HEE (KR)

International Classes:

C07C43/23; A23L33/00; A61K36/73; A61P3/10; C07C33/26

Other References:

KAMEDA K. ET AL.: "An alternative structure for botrallin, a metabolite of Botrytis Allii", TETRAHEDRON LETTERS, vol. 1, 1974, pages 103 - 106, XP027191328
ALY A.H. ET AL.: "Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense", JOURNAL OF NATURAL PRODUCTS, vol. 71, 2008, pages 972 - 980, XP055076124
BARROS COTA B. ET AL.: "Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi", FEMS MICROBIOL. LETT., vol. 285, 2008, pages 177 - 182, XP055076127
KURAMOCHI K. ET AL.: "Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, 2009, pages 7227 - 7238, XP055076128

Attorney, Agent or Firm:

LEE, Won-Hee (642-16 Yoksam-dongKangnam-ku, Seoul 135-080, KR)

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