Title:
NOVEL CELL MEMBRANE-PERMEABLE PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2007/049731
Kind Code:
A1
Abstract:
Disclosed is a novel cell membrane-permeable peptide which can transport a protein into a cell and/or a nucleus with a higher frequency than that in a conventional cell membrane-permeable peptide. Also disclosed is a pharmaceutical comprising the peptide.
Inventors:
UNO SHUSEI (JP)
KAMIDE KAEKO (JP)
NAKAKUBO HIROSHI (JP)
KAMIDE KAEKO (JP)
NAKAKUBO HIROSHI (JP)
Application Number:
PCT/JP2006/321465
Publication Date:
May 03, 2007
Filing Date:
October 27, 2006
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
UNO SHUSEI (JP)
KAMIDE KAEKO (JP)
NAKAKUBO HIROSHI (JP)
UNO SHUSEI (JP)
KAMIDE KAEKO (JP)
NAKAKUBO HIROSHI (JP)
International Classes:
C12N15/09; A61K45/00; A61K47/48; A61P37/08; C07K7/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| WO2003097671A1 | 2003-11-27 | |||
| WO2002018572A2 | 2002-03-07 | |||
| WO1998020016A1 | 1998-05-14 |
Foreign References:
| JP2003252802A | 2003-09-10 | |||
| US20040034888A1 | 2004-02-19 | |||
| JPS6433186A | 1989-02-03 | |||
| JP2004201547A | 2004-07-22 | |||
| JPH04346918A | 1992-12-02 | |||
| JPS6429930A | 1989-01-31 | |||
| JPH0929128A | 1997-02-04 | |||
| JPS6464743A | 1989-03-10 | |||
| JP2005013073A | 2005-01-20 | |||
| JP2005314355A | 2005-11-10 |
Other References:
NIKI S.: "Maku Toka Peptide o Mochiita Tanpakushitsu Saibonai Iso", KAGAKU TO SEIBUTSU, vol. 43, no. 10, 1 October 2005 (2005-10-01), pages 649 - 653, XP003011960
KONO K.: "Saibo no Naka eno Chokkobin-Maku Toka Peptide o Hyomei ni Motsu", RIBOSOME; CHEMICAL, vol. 57, no. 6, 2002, pages 51 - 52, XP003011961
PLENAT T. ET AL: "Interaction of primary amphipathic cell-penetrating peptides with phospholipid-supported monolayers", LANGMUIR, vol. 20, no. 21, 2004, pages 9255 - 9261, XP003011962
YOUSUKE N. ET AL: "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of corynebacterium efficiens", GENOME RESEARCH, vol. 13, 2003, pages 1572 - 1579, XP003011963
SATOSHI O. ET AL: "Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 21, 2001, pages 12215 - 12220, XP003011964
GLOCKNER F.O. ET AL: "Complet genome sequence of the marine planctomycete Pirelulla sp. strain 1", PROC. NATL. ACAD. SCI. USA, vol. 100, no. 14, 2003, pages 8298 - 8303, XP003011965
JAILLON O. ET AL: "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype", NATURE, vol. 431, 2004, pages 946 - 957, XP003011966
GREEN, M. ET AL., CELL, vol. 55, 1988, pages 1179 - 1188
FRANKEL, A.D. ET AL., CELL, vol. 55, 1988, pages 1189 - 1193
FAWELL, S. ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 664 - 668
NAGAHRA, H. ET AL., NATURE MEDICINE, vol. 4, 1998, pages 1449 - 1452
M. BODANSZKY, M.A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER, LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
NOBUO IZUMIYA: "iPeptide Gosei-no-Kiso to Jikken", 1975, MARUZEN CO.
HARUAKI YAJIMA, SHUNPEI SAKAKIBARA, SEIKAGAKU JIKKEN KOZA 1, TANPAKUSHITSU NO KAGAKU IV, vol. 205, 1977
"Peptide Synthesis", vol. 14, HIROKAWA SHOTEN, article "Zoku Iyakuhin no Kaihatsu"
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
W.S. EUM, MOLECULES AND CELLS, vol. 19, 2005, pages 191 - 197
M.N. LOBATO, T.H. RABBITTS, CURRENT MOLECULAR MEDICINE, vol. 4, 2004, pages 519 - 528
Y.Y. WHEELER, MOLECULAR THERAPY, vol. 8, 2003, pages 355 - 366
J APPL PHYSIOL, vol. 98, 2005, pages 1836 - 1845
CANCER RESEARCH, vol. 61, 2001, pages 7709 - 7712
PROC NATL ACAD SCI USA, vol. 99, 2002, pages 10423 - 10428
PROC NATL ACAD SCI USA, vol. 98, 2001, pages 11114 - 11119
NATURE MEDICINE, vol. 10, 2004, pages 305 - 309
ADVANCED DRUG DELIVERY REVIEWS, vol. 57, 2005, pages 637 - 651
ADVANCED DRUG DELIVERY REVIEWS, vol. 57, 2005, pages 529 - 546
J CONTROL RELEASE, vol. 102, no. 1, 20 January 2005 (2005-01-20), pages 247 - 53
KONO K.: "Saibo no Naka eno Chokkobin-Maku Toka Peptide o Hyomei ni Motsu", RIBOSOME; CHEMICAL, vol. 57, no. 6, 2002, pages 51 - 52, XP003011961
PLENAT T. ET AL: "Interaction of primary amphipathic cell-penetrating peptides with phospholipid-supported monolayers", LANGMUIR, vol. 20, no. 21, 2004, pages 9255 - 9261, XP003011962
YOUSUKE N. ET AL: "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of corynebacterium efficiens", GENOME RESEARCH, vol. 13, 2003, pages 1572 - 1579, XP003011963
SATOSHI O. ET AL: "Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 21, 2001, pages 12215 - 12220, XP003011964
GLOCKNER F.O. ET AL: "Complet genome sequence of the marine planctomycete Pirelulla sp. strain 1", PROC. NATL. ACAD. SCI. USA, vol. 100, no. 14, 2003, pages 8298 - 8303, XP003011965
JAILLON O. ET AL: "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype", NATURE, vol. 431, 2004, pages 946 - 957, XP003011966
GREEN, M. ET AL., CELL, vol. 55, 1988, pages 1179 - 1188
FRANKEL, A.D. ET AL., CELL, vol. 55, 1988, pages 1189 - 1193
FAWELL, S. ET AL., PROC. NATL. ACAD. SCI., vol. 91, 1994, pages 664 - 668
NAGAHRA, H. ET AL., NATURE MEDICINE, vol. 4, 1998, pages 1449 - 1452
M. BODANSZKY, M.A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER, LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
NOBUO IZUMIYA: "iPeptide Gosei-no-Kiso to Jikken", 1975, MARUZEN CO.
HARUAKI YAJIMA, SHUNPEI SAKAKIBARA, SEIKAGAKU JIKKEN KOZA 1, TANPAKUSHITSU NO KAGAKU IV, vol. 205, 1977
"Peptide Synthesis", vol. 14, HIROKAWA SHOTEN, article "Zoku Iyakuhin no Kaihatsu"
J. SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
W.S. EUM, MOLECULES AND CELLS, vol. 19, 2005, pages 191 - 197
M.N. LOBATO, T.H. RABBITTS, CURRENT MOLECULAR MEDICINE, vol. 4, 2004, pages 519 - 528
Y.Y. WHEELER, MOLECULAR THERAPY, vol. 8, 2003, pages 355 - 366
J APPL PHYSIOL, vol. 98, 2005, pages 1836 - 1845
CANCER RESEARCH, vol. 61, 2001, pages 7709 - 7712
PROC NATL ACAD SCI USA, vol. 99, 2002, pages 10423 - 10428
PROC NATL ACAD SCI USA, vol. 98, 2001, pages 11114 - 11119
NATURE MEDICINE, vol. 10, 2004, pages 305 - 309
ADVANCED DRUG DELIVERY REVIEWS, vol. 57, 2005, pages 637 - 651
ADVANCED DRUG DELIVERY REVIEWS, vol. 57, 2005, pages 529 - 546
J CONTROL RELEASE, vol. 102, no. 1, 20 January 2005 (2005-01-20), pages 247 - 53
Attorney, Agent or Firm:
TAKAYANAGI, Masau (Intellectual Property Department 2-6, Nihonbashi-honcho 2-chom, Chuo-ku Tokyo 05, JP)
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