Title:
NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING
Document Type and Number:
WIPO Patent Application WO/2012/064396
Kind Code:
A3
Abstract:
The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.
Inventors:
BROWN MILTON L (US)
PAIGE MIKELL (US)
TORESTSKY JEFFREY A (US)
UREN AYKUT (US)
KOSTURKO GEORGE (US)
BULUT GULLAY (US)
PAIGE MIKELL (US)
TORESTSKY JEFFREY A (US)
UREN AYKUT (US)
KOSTURKO GEORGE (US)
BULUT GULLAY (US)
Application Number:
PCT/US2011/048635
Publication Date:
September 27, 2012
Filing Date:
August 22, 2011
Export Citation:
Assignee:
UNIV GEORGETOWN (US)
BROWN MILTON L (US)
PAIGE MIKELL (US)
TORESTSKY JEFFREY A (US)
UREN AYKUT (US)
KOSTURKO GEORGE (US)
BULUT GULLAY (US)
BROWN MILTON L (US)
PAIGE MIKELL (US)
TORESTSKY JEFFREY A (US)
UREN AYKUT (US)
KOSTURKO GEORGE (US)
BULUT GULLAY (US)
International Classes:
A61K31/47; A01N43/42
Foreign References:
| US20100093794A1 | 2010-04-15 |
Other References:
LAZO ET AL.: "Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25", J MED CHEM., vol. 44, 2001, pages 4042 - 4049
PODESZWA ET AL.: "Investigating the antiproliferative activity of quinoline-5,8-diones and strylquinolinecarboxylic acids on tumor cell lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 17, 2007, pages 6138 - 6131
BREZAK ET AL.: "A novel synthetic inhibitor of CDC25 phosphatases: BN82002", CANCER RESEARCH, vol. 64, 2004, pages 3320 - 3325
GUO ET AL.: "Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma", ONCOGENE, vol. 23, 2004, pages 71 - 81
DATABASE PUBCHEM 26 March 2005 (2005-03-26), retrieved from http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=67583 Database accession no. 67583
PODESZWA ET AL.: "Investigating the antiproliferative activity of quinoline-5,8-diones and strylquinolinecarboxylic acids on tumor cell lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 17, 2007, pages 6138 - 6131
BREZAK ET AL.: "A novel synthetic inhibitor of CDC25 phosphatases: BN82002", CANCER RESEARCH, vol. 64, 2004, pages 3320 - 3325
GUO ET AL.: "Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma", ONCOGENE, vol. 23, 2004, pages 71 - 81
DATABASE PUBCHEM 26 March 2005 (2005-03-26), retrieved from http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=67583 Database accession no. 67583
Attorney, Agent or Firm:
BUCK, Todd, B. et al. (Lewis & Bockius LLP1111 Pennsylvania Avenue, N, Washington DC, US)
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