Title:
NOVEL FUSED PYRROLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/040166
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (1) below which is useful as a
glucocorticoid receptor function regulating agent, an anti-inflammatory drug
or an antidiabetic drug, or a pharmaceutically acceptable salt thereof. (1)
[In the formula, R1 represents an aralkyl group or the like; R2 represents
a hydrogen atom or the like; -W4=W5-W6=W7- represents
a group expressed as the following formula: -CR4=CR5-CR6=CR7- (wherein
R4, R5, R6 and R7 independently represent
a group expressed as the following formula: -E-A (wherein E represents a single
bond and A represents a hydrogen atom, a nitro group or the like)) or the like; R8
represents a group expressed as the following formula: -OR11 (wherein
R11 represents a hydrogen atom or the like) or the like; R9 represents
a trifluoromethyl group or the like; and R10 represents a group expressed
as the following formula: -[C(R13)R14]n-R15 (wherein
R13 and R14 independently represent a hydrogen atom or the
like, n represents an integer of 0-10, and R15 represents a group expressed
as the following formula: -N(R18)R19 (wherein R18
and R19 represent a monocyclic nitrogen-containing heterocyclic
ring or the like together with a nitrogen atom to which they are bonded) or the like).]
Inventors:
SONE TOSHIHIKO (JP)
SAWAKI RIEKO (JP)
NAKAJIMA TOMOKO (JP)
SAWAKI RIEKO (JP)
NAKAJIMA TOMOKO (JP)
Application Number:
PCT/JP2006/319426
Publication Date:
April 12, 2007
Filing Date:
September 29, 2006
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
SONE TOSHIHIKO (JP)
SAWAKI RIEKO (JP)
NAKAJIMA TOMOKO (JP)
SONE TOSHIHIKO (JP)
SAWAKI RIEKO (JP)
NAKAJIMA TOMOKO (JP)
International Classes:
C07D209/12; A61K31/404; A61K31/4045; A61K31/405; A61K31/4155; A61K31/427; A61K31/454; A61K31/496; A61K31/5377; A61K31/5386; A61K31/541; A61K31/551; A61P3/10; A61P5/44; A61P5/46; A61P29/00; C07D209/14; C07D209/22; C07D209/24; C07D401/06; C07D401/14; C07D403/06; C07D403/12; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D417/06; C07D491/107; C07D491/113; C07D497/10; C07D498/10
Domestic Patent References:
| WO2004067529A1 | 2004-08-12 | |||
| WO2004058733A1 | 2004-07-15 |
Foreign References:
| JP2005527555A | 2005-09-15 | |||
| JP2005529165A | 2005-09-29 | |||
| US20040235810A1 | 2004-11-25 | |||
| JPH11349869A | 1999-12-21 |
Other References:
DATABASE CAPLUS [online] OSIPOV S.N. ET AL.: "C-Alkylation of some heteroaromatic compounds by methyl trifluoropyruvate (trifluoroacetyl) imine", XP003011572, Database accession no. (1990:216562)
HASSINGER H.L. ET AL.: "Synthesis of indole-3-carboxamides via a haloform cleavage reaction of 3-trifluoroacetylindole with lithium dialkylamides", TETRAHEDRON LETTERS, vol. 39, no. 20, 1998, pages 3095 - 3098, XP004116202
DATABASE CAPLUS [online] GILBERT E.E. ET AL.: "Perhaloketones. XIX. Derivatives of benzo-N-heterocycles", XP003011573, Database accession no. (1969:491366)
DATABASE CAPLUS [online] KATO K. ET AL.: "Regio- and enantio-selective acetylation of 3,3,3-trifluoro-2-arylpropane-1,2-diols using Candida antarctica lipase", XP003011574, Database accession no. (2001:879854)
LYLE M.P.A. ET AL.: "Enantioselective Friedel-Crafts Alkylation Reactions Catalyzed by a Chiral Nonracemic C2-Symmetric 2,2'-Bipyridyl Copper(II) Complex", ORGANIC LETTERS, vol. 7, no. 5, 3 March 2005 (2005-03-03), pages 901 - 904, XP003011575
ABID M. ET AL.: "Cinchona alkaloid induced chiral discrimination for the induced chiral discrimination for the determination of the enantiomeric composition of alpha-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy", TETRAHEDRON: ASYMMETRY, vol. 16, no. 8, 18 April 2005 (2005-04-18), pages 1547 - 1555, XP004842448
EL KAIM L. ET AL.: "New access to fluorinated glycolic acid derivatives from trifluoropyruvamides", TETRAHEDRON LETTERS, vol. 37, no. 3, 1996, pages 375 - 378, XP004030369
HASSINGER H.L. ET AL.: "Synthesis of indole-3-carboxamides via a haloform cleavage reaction of 3-trifluoroacetylindole with lithium dialkylamides", TETRAHEDRON LETTERS, vol. 39, no. 20, 1998, pages 3095 - 3098, XP004116202
DATABASE CAPLUS [online] GILBERT E.E. ET AL.: "Perhaloketones. XIX. Derivatives of benzo-N-heterocycles", XP003011573, Database accession no. (1969:491366)
DATABASE CAPLUS [online] KATO K. ET AL.: "Regio- and enantio-selective acetylation of 3,3,3-trifluoro-2-arylpropane-1,2-diols using Candida antarctica lipase", XP003011574, Database accession no. (2001:879854)
LYLE M.P.A. ET AL.: "Enantioselective Friedel-Crafts Alkylation Reactions Catalyzed by a Chiral Nonracemic C2-Symmetric 2,2'-Bipyridyl Copper(II) Complex", ORGANIC LETTERS, vol. 7, no. 5, 3 March 2005 (2005-03-03), pages 901 - 904, XP003011575
ABID M. ET AL.: "Cinchona alkaloid induced chiral discrimination for the induced chiral discrimination for the determination of the enantiomeric composition of alpha-trifluoromethylated-hydroxyl compounds by 19F NMR spectroscopy", TETRAHEDRON: ASYMMETRY, vol. 16, no. 8, 18 April 2005 (2005-04-18), pages 1547 - 1555, XP004842448
EL KAIM L. ET AL.: "New access to fluorinated glycolic acid derivatives from trifluoropyruvamides", TETRAHEDRON LETTERS, vol. 37, no. 3, 1996, pages 375 - 378, XP004030369
Attorney, Agent or Firm:
ISOBE, Yutaka et al. (Dainippon Sumitomo Pharma Co., Ltd.,, 1-98, Kasugadenaka 3-chome,, Konohana-ku, Osaka-sh, Osaka 22, JP)
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