Title:
NOVEL IMAGING AGENTS COMPRISING CASPASE-3 INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005053752
Kind Code:
A3
Abstract:
The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the caspase-3 inhibitor, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.
Inventors:
HISCOCK DUNCAN (GB)
NEWTON BEN (GB)
GUILBERT BENEDICTE (GB)
NEWTON BEN (GB)
GUILBERT BENEDICTE (GB)
Application Number:
PCT/GB2004/005003
Publication Date:
October 06, 2005
Filing Date:
November 26, 2004
Export Citation:
Assignee:
GE HEALTHCARE LTD (GB)
HISCOCK DUNCAN (GB)
NEWTON BEN (GB)
GUILBERT BENEDICTE (GB)
HISCOCK DUNCAN (GB)
NEWTON BEN (GB)
GUILBERT BENEDICTE (GB)
International Classes:
A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/14; A61K51/00; A61K51/04; A61K51/06; A61K51/08; (IPC1-7): A61K51/00; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/14; A61K51/02; A61K51/04; A61K51/06; A61K51/08
Domestic Patent References:
| WO2001089584A2 | 2001-11-29 | |||
| WO2004069773A1 | 2004-08-19 |
Foreign References:
| US6589503B1 | 2003-07-08 |
Other References:
HABERKORN UWE; KINSCHERF RALF; KRAMMER PETER H; MIER WALTER; EISENHUT MICHAEL: "Investigation of a potential scintigraphic marker of apoptosis: Radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone", NUCLEAR MEDICINE AND BIOLOGY, vol. 28, no. 7, October 2001 (2001-10-01), pages 793 - 798, XP002333221
DECKWERTH ET AL: "Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors", DRUG DEVELOPMENT RESEARCH, vol. 52, no. 4, April 2001 (2001-04-01), pages 579 - 586, XP002333222
BHARATHI ET AL: "Noninvasive real-time imaging of apoptosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATE OF AMERICA, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 16551 - 16555, XP002333223
DECKWERTH ET AL: "Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors", DRUG DEVELOPMENT RESEARCH, vol. 52, no. 4, April 2001 (2001-04-01), pages 579 - 586, XP002333222
BHARATHI ET AL: "Noninvasive real-time imaging of apoptosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATE OF AMERICA, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 16551 - 16555, XP002333223
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