Title:
NOVEL LONG-ACTING POLYPEPTIDE COMPOUND, COMPOSITION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/098718
Kind Code:
A1
Abstract:
Provided are a novel long-acting polypeptide compound, a composition, and a use thereof. In the long-acting polypeptide compound, the substitution of an amino acid at a key particular position enhances the stability, activity and hydrolysis resistance of a polypeptide. By means of a large number of trials, after amino acid position 2 and/or 3 of the backbone of the polypeptide compound is substituted by an unnatural amino acid AiB, Iva or Cba, the stability, activity and hydrolysis resistance of polypeptide molecules are significantly enhanced, and the respective substitution of the amino acid position 27 and/or 28 by an L and/or D amino acid can also significantly enhance the activity of the polypeptide molecules. The long-acting polypeptide compound has a long half-life period, and has good pharmacodynamic effects of treating diabetes and reducing weight.
Inventors:
HU FEIFEI (CN)
LI CHUNYAN (CN)
LI CHUNYAN (CN)
Application Number:
PCT/CN2023/096029
Publication Date:
May 16, 2024
Filing Date:
May 24, 2023
Export Citation:
Assignee:
NEIMENGGU BORUIJINGCHUANG BIOTECH CO LTD (CN)
International Classes:
C07K14/605; A23L33/18; A61K38/26; A61P3/10; C07K1/20
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
Download PDF: