NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS

WIPO Patent Application WO2005115150

A3

The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.

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WO/1996/007096	AN IN VITRO SYSTEM FOR DETERMINING FORMATION OF A'beta' AMYLOID
JP2024507747	Heteroaryl compounds, their compositions and uses as RIP2 kinase inhibitors

LYNCH KEVIN R (US)
MACDONALD TIMOTHY L (US)
HEASLEY BRIAN H (US)

PCT/US2005/016011

May 04, 2006

May 06, 2005

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UNIV VIRGINIA (US)
LYNCH KEVIN R (US)
MACDONALD TIMOTHY L (US)
HEASLEY BRIAN H (US)

A61K31/66; A01N57/00; C07F9/02; C07F9/09; C07F9/38; C07F9/40; C07F9/572; C07F9/58; C07F9/6506; C07F9/655

DATABASE CAPLUS [online] HOPPER ET AL: "Facile Synthesis of Lysophospholipids Containing Unsaturated Fatty Acid Chains", XP002993967, accession no. STN Database accession no. 667299

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