Title:
NOVEL METALLO-BETA-LACTAMASE INHIBITOR CREATED IN MULTI-DRUG RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/101030
Kind Code:
A1
Abstract:
The present invention relates to a novel metallo-beta-lactamase (MBL) inhibitor and an antibacterial composition to be used against multi-drug resistant bacteria, containing same, and is a compound of chemical formula 1 or a derivative thereof, and, more specifically, is 3,5-dichlorophenylboronic acid, (4-(4-amino-3- chlorophenoxy)-3,5-dichlorophenyl) boronic acid and (3,5-dichloro-4-(2-hydroxyethoxy)phenyl)boronic acid. An MBL inhibitor of chemical formula 1, according to the present invention, has an inhibitory activity against a broad spectrum of MBLs. Therefore, when an MBL according to the present invention and an antibiotic having a β-lactam structure are used together in treatment, degradation of the antibiotic due to MBL produced by microorganisms is prevented so that the duration of action and range of the antibiotic can be extended, and bacteria that can acquire resistance to an antibiotic due to the presence of MBL can be killed, and thus infection by multi-drug resistant bacteria is effectively prevented and treated.
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Inventors:
LEE SANG HEE (KR)
LEE JUNG HUN (KR)
JEON JEONG HO (KR)
LEE JUNG HUN (KR)
JEON JEONG HO (KR)
Application Number:
PCT/KR2020/011578
Publication Date:
May 27, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
MYONGJI UNIV INDUSTRY AND ACADEMIA COOPERATION FOUNDATION (KR)
International Classes:
C07F5/02; A61K31/69; A61P31/00
Domestic Patent References:
| WO2008063300A2 | 2008-05-29 | |||
| WO2018215800A1 | 2018-11-29 | |||
| WO2018215799A1 | 2018-11-29 |
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WORTHINGTON ET AL., J. ORG. CHEM., vol. 78, 2013, pages 4207
LEE ET AL., LANCET INFECT. DIS., vol. 16, 2016, pages 17 - 18
MCKENNA, NATURE, vol. 499, 2013, pages 394 - 396
PAPP-WALLACE ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 55, 2011, pages 4943 - 4960
TUCKER ET AL., CELL, vol. 172, 2018, pages 618
BUSH ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 54, 2010, pages 969 - 976
GALLENI ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 45, 2001, pages 660 - 663
PALZKILL, ANN. N. Y. ACAD. SCI., vol. 1277, 2013, pages 91 - 104
NORDMANN ET AL., TRENDS MICROBIOL., vol. 19, 2011, pages 588 - 595
WALSH ET AL., CLIN. MICROBIOL. REV., vol. 18, 2005, pages 306 - 325
YONG ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 53, 2009, pages 5046 - 5054
ITO ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 39, 1995, pages 824 - 829
CORNAGLIA ET AL., CLIN. INFECT. DIS., vol. 31, 2000, pages 1119 - 1125
LAURETTI ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 43, 1999, pages 1584 - 1590
BELLAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 44, 2000, pages 1878 - 1886
CASTANHEIRA ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 48, 2004, pages 4654 - 4661
RIEBER H ET AL., J. ANTIMICROB. CHEMOTHER., vol. 67, 2012, pages 1043 - 1045
MASSIDDA ET AL., J. BACTERIOL., vol. 173, 1991, pages 4611 - 4617
BLOCH ET AL., MEDICINE (BALTIMORE), vol. 76, 1997, pages 30 - 41
LEE ET AL., J. CHIN. MED. ASSOC., vol. 71, 2008, pages 473 - 476
SHINHA ET AL., IDCASES, vol. 2, 2015, pages 13215
LOMOVSKAYA ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 61, 2017, pages e01443 - 17
ZHANEL ET AL., DRUGS, vol. 78, 2018, pages 65
PAGE, BIOCHEM. J., vol. 295, 1993, pages 295 - 304
KING ET AL., PROTEIN SCI., vol. 20, 2011, pages 1484 - 1491
ABAGYAN ET AL., J. MOL. BIOL., vol. 235, 1994, pages 983 - 1002
TIMURKAYNAK ET AL., INT. J. ANTIMICROB. AGENTS, vol. 27, 2006, pages 224 - 228
PARK ET AL., J. GLOB. ANTIMICROB. RESIST., vol. 14, 2018, pages 302 - 305
Attorney, Agent or Firm:
YOON, Yuh-Gang (KR)
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