Title:
NOVEL METHOD FOR SYNTHESISING DERIVATIVES OF (2S, 3AS, 7AS)-1-[(S)-ALANYL]-OCTAHYDRO,-IH-INDOLE-2-CARBOXYLIC ACID AND THE USE THEREOF FOR PERINDOPRIL SYNTHESIS
Document Type and Number:
WIPO Patent Application WO2004078708
Kind Code:
A3
Abstract:
The invention relates to a method for synthesising compounds of the formula (I), wherein R1 is a hydrogen atom or an alkyl or benzyl group, and R2 is amine function protecting group. The use of said compounds for synthesising perindopril and the pharmaceutically acceptable salts thereof is also disclosed.
Inventors:
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
LANGLOIS PASCAL (FR)
Application Number:
PCT/FR2004/000445
Publication Date:
October 14, 2004
Filing Date:
February 27, 2004
Export Citation:
Assignee:
SERVIER LAB (FR)
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
DUBUFFET THIERRY (FR)
LANGLOIS PASCAL (FR)
International Classes:
C07D209/42; C07K5/02; C07K5/06; (IPC1-7): C07K5/06; C07D209/42; C07K5/02
Domestic Patent References:
| WO2003016336A1 | 2003-02-27 | |||
| WO2001058868A1 | 2001-08-16 |
Foreign References:
| US4933361A | 1990-06-12 |
Other References:
VINCENT M ET AL: "Stereoselective Synthesis of a New Perhydroindole Derivative of Chiral Iminodiacid, a Potent Inhibitor of Agiotensin Converting Enzyme", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 23, no. 16, 1982, pages 1677 - 1680, XP002155080, ISSN: 0040-4020
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