Title:
NOVEL METHOD FOR SYNTHESIZING DECURSIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/058875
Kind Code:
A1
Abstract:
The present invention relates to a novel method for synthesizing a decursin derivative, enabling high-yield mass synthesis of a decursin derivative (PRG-A-04) represented by compound I through a reaction between decursinol and an intermediate compound in which a Boc protecting group is introduced to an OH group of 3-(3-methoxy-4-nitrophenyl)prop-2-en-1-ol in the presence of a platinum catalyst and xantphos.
Inventors:
KIM MIN JU (KR)
Application Number:
PCT/KR2022/011763
Publication Date:
April 13, 2023
Filing Date:
August 08, 2022
Export Citation:
Assignee:
PRG S&TECH INC (KR)
International Classes:
C07D493/04; A61K31/37
Foreign References:
| KR20180119490A | 2018-11-02 | |||
| KR20210052326A | 2021-05-10 | |||
| KR20100008808A | 2010-01-27 | |||
| KR20210052326A | 2021-05-10 |
Other References:
LEE, K. ET AL: "Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 12, 1 December 2010 (2010-12-01), AMSTERDAM, NL , pages 5567 - 5575, XP027526514, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2010.09.006
LEE WONHWA; YUSEOK O.; LEE CHANGHUN; JEONG SO YEON; LEE JEE-HYUN; BAEK MOON-CHANG; SONG GYU-YONG; BAE JONG-SUP: "Suppressive activities of KC1–3 on HMGB1-mediated septic responses", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 163, 1 January 1900 (1900-01-01), US , pages 260 - 268, XP085659313, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2019.02.027
LEE WONHWA; YUSEOK O.; LEE CHANGHUN; JEONG SO YEON; LEE JEE-HYUN; BAEK MOON-CHANG; SONG GYU-YONG; BAE JONG-SUP: "Suppressive activities of KC1–3 on HMGB1-mediated septic responses", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 163, 1 January 1900 (1900-01-01), US , pages 260 - 268, XP085659313, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2019.02.027
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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