Title:
NOVEL PEPTIDE DERIVATIVES, PREPARATION AND THERAPEUTIC AND COSMETIC APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO2003064458
Kind Code:
A3
Abstract:
The invention relates to peptides of formula (1) R-V -Ala<2>-His<3>-X<4>-Y<5>-Trp <5>-NH2 wherein R represents a hydrogen atom or a protective group which can be chosen from among a benzoyl group, a tosyl group, a benzene sulfonyl group, a benzyloxycarbonyl group or a pyridinepropionyl group; V represents a natural amino acid or not chosen from among norleucine, norvaline and 2-N-Me-norleucine, X represents a natural amino acid or not having an aromatic character chosen from among phenylalanine, 1-naphtylalanine, 2-naphtylalanine, phenylglycine, benzothienylalanine, 4,4'-biphenylalanine, 3,3-diphenylalanine, homophenylalanine, indanylglycine, 4-methylphenylalanine, thienylalanine, p-nitrophenylalanine, halogenophenylalanine of configuration L or D; Y represents a natural amino acid of configuration L, having a basic character chosen from among arginine, lysine or ornithine, the enantiometers or diastereoisomers, and the mixtures thereof, including racemic mixtures. The invention also relates to a method for the preparation and application thereof in the field of therapeutics or cosmetics.
Inventors:
PINEL ANNE-MARIE (FR)
Application Number:
PCT/FR2003/000300
Publication Date:
March 25, 2004
Filing Date:
January 31, 2003
Export Citation:
Assignee:
INST EUROPEEN BIOLOG CELLULAIR (FR)
PINEL ANNE-MARIE (FR)
PINEL ANNE-MARIE (FR)
International Classes:
A61K8/00; A61K8/64; A61K38/00; A61P11/06; A61K8/30; A61P17/00; A61P17/06; A61P17/14; A61P17/16; A61P37/08; A61Q5/10; A61Q19/00; C07K1/04; C07K7/06; (IPC1-7): C07K14/685; A61K7/42; A61K38/34; A61P17/00
Domestic Patent References:
| WO2001090140A1 | 2001-11-29 | |||
| WO1999054358A1 | 1999-10-28 |
Foreign References:
| FR2753707A1 | 1998-03-27 |
Other References:
See also references of EP 1470157A2
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