Title:
NOVEL PROTEIN SPECIFICALLY BINDING TO CALRETICULIN AND HAVING HUMAN FIBRONECTIN DOMAIN III SCAFFOLD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/075713
Kind Code:
A1
Abstract:
The present invention provides a novel protein specifically binding to calreticulin and having the scaffold of human fibronectin domain III and a use thereof, wherein the protein can be used for diagnosing cell damage in an early stage to early determine cancer therapy effects and rapidly evaluate in vivo toxicity, thus finding advantageous applications as a candidate material for probes for in vivo diagnosis and treatment of cancer.
Inventors:
HONG YEONGJIN (KR)
MIN JUNG-JOON (KR)
KIM DONG-YEON (KR)
PYO AYOUNG (KR)
YOU SUNG-HWAN (KR)
THANGAM RAMAR (KR)
MIN JUNG-JOON (KR)
KIM DONG-YEON (KR)
PYO AYOUNG (KR)
YOU SUNG-HWAN (KR)
THANGAM RAMAR (KR)
Application Number:
PCT/KR2021/013640
Publication Date:
April 14, 2022
Filing Date:
October 05, 2021
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C07K14/78; A61K38/00; A61K47/62; A61K49/00; A61K51/08; A61P35/00; C07K14/47
Domestic Patent References:
| WO2020172601A1 | 2020-08-27 |
Foreign References:
| KR101636882B1 | 2016-07-06 | |||
| US5854202A | 1998-12-29 | |||
| US20190365913A1 | 2019-12-05 | |||
| KR20200001971A | 2020-01-07 |
Other References:
VAN AGTHOVEN JOHANNES F, XIONG JIAN-PING, ALONSO JOSÉ LUIS, RUI XIANLIANG, ADAIR BRIAN D, GOODMAN SIMON L, ARNAOUT M AMIN: "Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 21, no. 4, 1 April 2014 (2014-04-01), New York , pages 1 - 20, XP055920470, ISSN: 1545-9993, DOI: 10.1038/nsmb.2797
ZHANG YING, THANGAM RAMAR, YOU SUNG-HWAN, SULTONOVA RUKHSORA D., VENU AKHIL, MIN JUNG-JOON, HONG YEONGJIN: "Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy", CANCERS, vol. 13, no. 11, 1 January 2021 (2021-01-01), pages 1 - 18, XP055920476, DOI: 10.3390/cancers13112801
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AI ET AL., BIOCHEMISTRY, vol. 46, no. 20, 2007, pages 5904 - 5910
MENA ET AL., NAT. BIOTECHNOL., vol. 24, 2006, pages 1569 - 1571
SUBACH ET AL., CHEM. BIOL., vol. 15, no. 10, 2008, pages 1116 - 1124
WANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 16745 - 16749
KOGURE ET AL., METHODS, vol. 45, no. 3, 2008, pages 223 - 226
FRADKOV ET AL., BIOCHEM. J., vol. 368, 2002, pages 17 - 21
SHKROB ET AL., BIOCHEM. J., vol. 392, 2005, pages 649 - 654
JACOBSON ET AL., BIOCONJUG. CHEM., vol. 22, no. 3, 2011, pages 422 - 428
PLOS ONE, vol. 12, no. 7, 7 July 2017 (2017-07-07), pages e0180786
ZHANG YING, THANGAM RAMAR, YOU SUNG-HWAN, SULTONOVA RUKHSORA D., VENU AKHIL, MIN JUNG-JOON, HONG YEONGJIN: "Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy", CANCERS, vol. 13, no. 11, 1 January 2021 (2021-01-01), pages 1 - 18, XP055920476, DOI: 10.3390/cancers13112801
EYFP, TSIEN, ANNU. REV. BIOCHEM., vol. 67, 1998, pages 509 - 544
PEDELACQ ET AL., NAT. BIOTECH., vol. 24, 2006, pages 79 - 88
PRENDERGAST ET AL., BIOCHEM., vol. 17, no. 17, 1978, pages 3448 - 3453
KARASAWA ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 34167 - 34171
SHAGIN ET AL., MOL. BIOL. EVOL., vol. 21, no. 5, 2004, pages 841 - 850
MATZ ET AL., NAT. BIOTECHNOL., vol. 17, 1999, pages 969 - 973
ZAPATA-HOMMER ET AL., BMC BIOTECHNOL., vol. 3, 2003, pages 5
HAT ET AL., ANN. N. Y. ACAD. SCI., vol. 1, 2002, pages 627 - 633
NAGAI ET AL., NAT. BIOTECHNOL., vol. 20, no. 1, 2002, pages 87 - 90
GRIESBECK ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 29188 - 29194
NGUYETDAUGHERTY, NAT. BIOTECHNOL., vol. 23, no. 3, 2005, pages 355 - 360
FRADKOV ET AL., NAT. BIOTECHNOL., vol. 22, no. 3, 2004, pages 1567 - 1572
KREDEL ET AL., PLOS ONE, vol. 4, no. 2, 2009, pages e4391
SHANER ET AL., NAT. METHODS, vol. 5, no. 6, 2008, pages 545 - 551
SHANNER ET AL., NAT. BIOTEHCNOL., vol. 22, 2004, pages 1567 - 1572
CAMPBELL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, no. 12, 2002, pages 7877 - 7882
KARAWAWA ET AL., BIOCHEM. J., vol. 381, 2004, pages 307 - 312
MERZLYAK ET AL., NAT. METHODS, vol. 4, no. 7, 2007, pages 555 - 557
BAIRD ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, 1999, pages 11984 - 11989
CUBITT ET AL., TRENDS BIOCHEM. SCI., vol. 20, 1995, pages 448 - 455
AI ET AL., BIOCHEM. J., vol. 400, no. 3, 2006, pages 531 - 540
KOUSHIK ET AL., BIOPHYS. J., vol. 91, no. 12, 2006, pages L99 - L101
AI ET AL., BIOCHEMISTRY, vol. 46, no. 20, 2007, pages 5904 - 5910
MENA ET AL., NAT. BIOTECHNOL., vol. 24, 2006, pages 1569 - 1571
SUBACH ET AL., CHEM. BIOL., vol. 15, no. 10, 2008, pages 1116 - 1124
WANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 16745 - 16749
KOGURE ET AL., METHODS, vol. 45, no. 3, 2008, pages 223 - 226
FRADKOV ET AL., BIOCHEM. J., vol. 368, 2002, pages 17 - 21
SHKROB ET AL., BIOCHEM. J., vol. 392, 2005, pages 649 - 654
JACOBSON ET AL., BIOCONJUG. CHEM., vol. 22, no. 3, 2011, pages 422 - 428
PLOS ONE, vol. 12, no. 7, 7 July 2017 (2017-07-07), pages e0180786
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
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