Title:
NOVEL UDP-GLYCOSYLTRANSFERASE DERIVED FROM GINSENG AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/051215
Kind Code:
A1
Abstract:
The present invention relates to a novel uridine diphosphate (UDP)-glycosyltransferase, and particularly to a novel UDP-glycosyltransferase derived from ginseng and use thereof, a method for preparing glycosylated ginsenoside by converting protopanaxadiol (PPD)-type ginsenoside using the UDP-glycosyltransferase, a composition for converting the PPD-type ginsenoside into glycosylated ginsenoside, comprising the UDP-glycosyltransferase, a transformant or a culture thereof as active ingredients, a method for enhancing the expression of the UDP-glycosyltransferase using MeJA (methyl jasmonate), and a composition for enhancing the expression of the UDP-glycosyltransferase, which comprises MeJA as an active ingredient.
Inventors:
KIM SUN CHANG (KR)
CHOI GIL TSU (KR)
JUNG SUK CHAE (KR)
KIM WOO HYUN (KR)
IM WAN TAEK (KR)
LEE YEON (KR)
CHOI GIL TSU (KR)
JUNG SUK CHAE (KR)
KIM WOO HYUN (KR)
IM WAN TAEK (KR)
LEE YEON (KR)
Application Number:
PCT/KR2012/011402
Publication Date:
April 03, 2014
Filing Date:
December 24, 2012
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
INTELLIGENT SYNTHETIC BIOLOGY CT (KR)
INTELLIGENT SYNTHETIC BIOLOGY CT (KR)
International Classes:
C12N9/10; C07K14/415; C12N15/54; C12N15/63
Other References:
IM, OK TAE ET AL.: "Stimulation of Rg3 ginsenoside biosynthesis in ginseng hairy roots elicited by methyl jasmonate", PLANT CELL, TISSUE AND ORGAN CULTURE, vol. 112, no. 1, 26 August 2012 (2012-08-26), pages 87 - 93, XP035138637
SUN, CHAO ET AL.: "De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis", BMC GENOMICS, vol. 111, no. 262, 24 April 2010 (2010-04-24), pages 1 - 12, XP021072582
CHEN, S. ET AL.: "454 EST analysis detects genes putatively involved in gins enoside biosynthesis in Panax ginseng", PLANT CELL REPORTS, vol. 30, no. 9, 12 April 2011 (2011-04-12), pages 1593 - 1601, XP019938026
LUO, HONGMEI ET AL.: "Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers", BMC GENOMICS, vol. 12, no. ISSUE, 23 December 2011 (2011-12-23), pages 1 - 15, XP021111659
SAITO, KAZUKI. ET AL.: "Triterpenoid biosynthesis and engineering in plants", FRONTIERS IN PLANT SCIENCE, vol. 2, no. 25, 30 June 2011 (2011-06-30), pages 1 - 8, XP055244974
See also references of EP 2900812A4
SUN, CHAO ET AL.: "De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis", BMC GENOMICS, vol. 111, no. 262, 24 April 2010 (2010-04-24), pages 1 - 12, XP021072582
CHEN, S. ET AL.: "454 EST analysis detects genes putatively involved in gins enoside biosynthesis in Panax ginseng", PLANT CELL REPORTS, vol. 30, no. 9, 12 April 2011 (2011-04-12), pages 1593 - 1601, XP019938026
LUO, HONGMEI ET AL.: "Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers", BMC GENOMICS, vol. 12, no. ISSUE, 23 December 2011 (2011-12-23), pages 1 - 15, XP021111659
SAITO, KAZUKI. ET AL.: "Triterpenoid biosynthesis and engineering in plants", FRONTIERS IN PLANT SCIENCE, vol. 2, no. 25, 30 June 2011 (2011-06-30), pages 1 - 8, XP055244974
See also references of EP 2900812A4
Attorney, Agent or Firm:
SON, Min (STX R&D Center 6th Floor,163, YangJaeCheon-ro, Gangnam-gu, Seoul 135-855, KR)
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