Title:
NS1-BINDING PROTEIN
Document Type and Number:
WIPO Patent Application WO/2020/043066
Kind Code:
A1
Abstract:
Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and comprising specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue virus. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.
Inventors:
CUI PENG (CN)
HE ZHIQIANG (CN)
MENG YUAN (CN)
ZHONG DONGMEI (CN)
HE ZHIQIANG (CN)
MENG YUAN (CN)
ZHONG DONGMEI (CN)
Application Number:
PCT/CN2019/102629
Publication Date:
March 05, 2020
Filing Date:
August 26, 2019
Export Citation:
Assignee:
DONGGUAN PENGZHI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K16/10; G01N33/569; G01N33/577
Foreign References:
| US20170233460A1 | 2017-08-17 | |||
| CN109081869A | 2018-12-25 | |||
| US20130164734A1 | 2013-06-27 | |||
| CN104357401A | 2015-02-18 |
Other References:
"Preparation of Single Domain Heavy Chain Antibodies and Monoclonal Antibodies Against Nonstructural Protein 1 of Dengue Virus Type 2 and Comparative Research Applied to Immunoassay", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES, 15 January 2014 (2014-01-15)
ROCHA, L. B. ET AL.: "Epitope sequences in Dengue virus NS1 protein identified by monoclonal antibodies", ANTIBODIES, 15 October 2017 (2017-10-15), XP055696961
GELANEW, T. ET AL.: "Development and characterization of serotype-specific monoclonal antibodies against the dengue virus-4(DENV-4) non-structural protein(NSl", VIROLOGY JOURNAL, 6 February 2018 (2018-02-06), XP055606816
ROCHA, L. B. ET AL.: "Epitope sequences in Dengue virus NS1 protein identified by monoclonal antibodies", ANTIBODIES, 15 October 2017 (2017-10-15), XP055696961
GELANEW, T. ET AL.: "Development and characterization of serotype-specific monoclonal antibodies against the dengue virus-4(DENV-4) non-structural protein(NSl", VIROLOGY JOURNAL, 6 February 2018 (2018-02-06), XP055606816
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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