Title:
NUCLEOSIDE DERIVATIVE HAVING MULTI-TARGET KINASE INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2022/260336
Kind Code:
A3
Abstract:
The present invention relates to a nucleoside derivative, which can be used for the prevention or treatment of cancer by inhibiting a kinase, and a pharmaceutical composition comprising same, wherein the nucleoside derivative has inhibitory activity against kinases such as NTRK1, CSNK1D, DYRK1A, DYRK1B, and FLT3, and thus, exhibits inhibitory activity against various cancer cells directly or indirectly related to the kinase, so that the nucleoside derivative can be used to prevent or treat various cancers such as lung cancer, colon cancer, breast cancer, liver cancer, stomach cancer, and prostate cancer.
Inventors:
JEONG LAK SHIN (KR)
LEE SANG KOOK (KR)
TRIPATHI SUSHIL KUMAR (KR)
MASHELKAR KARISHMA K (KR)
SUNG KI SU (KR)
YUM YUN A (KR)
KWON JEE YOUN (KR)
LEE SANG KOOK (KR)
TRIPATHI SUSHIL KUMAR (KR)
MASHELKAR KARISHMA K (KR)
SUNG KI SU (KR)
YUM YUN A (KR)
KWON JEE YOUN (KR)
Application Number:
PCT/KR2022/007747
Publication Date:
February 02, 2023
Filing Date:
May 31, 2022
Export Citation:
Assignee:
FUTURE MEDICINE CO LTD (KR)
International Classes:
C07H19/167; A61K31/7064; A61P35/00; C07D487/04
Foreign References:
| US4140851A | 1979-02-20 | |||
| US20200215153A1 | 2020-07-09 |
Other References:
BOBEK M, WHISTLER R L, BLOCH A: "Synthesis and biological activity of 4'-thio analogs of the antibiotic toyocamycin", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 2, 1 January 1972 (1972-01-01), AMSTERDAM, NL , pages 168 - 171, XP002977599, ISSN: 0223-5234, DOI: 10.1021/jm00272a011
KVĚTA KALÍKOVÁ; MARKÉTA VOBORNÁ; EVA TESAŘOVÁ: "Chromatographic behavior of new deazapurine ribonucleosides in hydrophilic interaction liquid chromatography", ELECTROPHORESIS, VERLAG CHEMIE, HOBOKEN, USA, vol. 39, no. 16, 8 July 2018 (2018-07-08), Hoboken, USA, pages 2144 - 2151, XP071504471, ISSN: 0173-0835, DOI: 10.1002/elps.201800141
1 February 2017 (2017-02-01), PARK SUL-GI, KIM SANG-HUN, KIM KWANG-YOUN, YU SUN-NYOUNG, CHOI HYEUN-DEOK, KIM YOUNG-WOOK, NAM HYO-WON, SEO YOUNG-KYO, AHN SOON-CH: "Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells", XP009542967
KVĚTA KALÍKOVÁ; MARKÉTA VOBORNÁ; EVA TESAŘOVÁ: "Chromatographic behavior of new deazapurine ribonucleosides in hydrophilic interaction liquid chromatography", ELECTROPHORESIS, VERLAG CHEMIE, HOBOKEN, USA, vol. 39, no. 16, 8 July 2018 (2018-07-08), Hoboken, USA, pages 2144 - 2151, XP071504471, ISSN: 0173-0835, DOI: 10.1002/elps.201800141
1 February 2017 (2017-02-01), PARK SUL-GI, KIM SANG-HUN, KIM KWANG-YOUN, YU SUN-NYOUNG, CHOI HYEUN-DEOK, KIM YOUNG-WOOK, NAM HYO-WON, SEO YOUNG-KYO, AHN SOON-CH: "Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells", XP009542967
Attorney, Agent or Firm:
YOUNGBEE INTELLECTUAL PROPERTY (KR)
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