Title:
ORAL DOSAGE FORM FOR ADMINISTRATION OF THE COMBINATION OF TEGAFUR, URACIL, FOLINIC ACID, AND OXALIPLATIN AND METHOD OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO2001066102
Kind Code:
A3
Abstract:
This invention provides a dosage form and a method of administering an anti-tumor composition comprising tegafur, uracil and folinic acid to potentiate the coadministration of oxaliplatin.
Inventors:
CHAZARD MICHEL (FR)
Application Number:
PCT/US2001/006730
Publication Date:
December 20, 2001
Filing Date:
March 01, 2001
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
CHAZARD MICHEL (FR)
CHAZARD MICHEL (FR)
International Classes:
A61K31/496; A61K31/505; A61K31/513; A61K31/519; A61K33/243; A61K45/06; (IPC1-7): A61K31/495; A61K31/505; A61P35/00
Other References:
HOFF P M ET AL: "Oxaliplatin and UFT /oral calcium folinate for advanced colorectal carcinoma.", ONCOLOGY, (1999 JUL) 13 (7 SUPPL 3) 48-50., XP001021450
LOUVET, C. (1) ET AL: "Antitumor activity of UFT plus folinic acid (FA) in combination with oxaliplatin (Ox) against human HT29 colon cancer xenografts in athymic nude mice.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, (MARCH, 1999) VOL. 40, PP. 292. MEETING INFO.: 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA, PENNSYLVANIA, USA APRIL 10-14, 1999 AMERICAN, XP001019025
HOFFMANN W. ET AL: "UFT plus calcium folinate plus radiotherapy for recurrent rectal cancer.", ONCOLOGY, (1999) 13/7 SUPPL. (125-126)., XP001021447
LOUVET, C. (1) ET AL: "Antitumor activity of UFT plus folinic acid (FA) in combination with oxaliplatin (Ox) against human HT29 colon cancer xenografts in athymic nude mice.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, (MARCH, 1999) VOL. 40, PP. 292. MEETING INFO.: 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA, PENNSYLVANIA, USA APRIL 10-14, 1999 AMERICAN, XP001019025
HOFFMANN W. ET AL: "UFT plus calcium folinate plus radiotherapy for recurrent rectal cancer.", ONCOLOGY, (1999) 13/7 SUPPL. (125-126)., XP001021447
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