Title:
ORALLY DISSOLVING MUCOADHESIVE FILMS UTILIZING MENTHOL AND L-ARGININE TO ENHANCE THE BIOAVAILABILITY OF CANNABINOIDS
Document Type and Number:
WIPO Patent Application WO/2021/112812
Kind Code:
A3
Abstract:
A method for providing an orally dissolvable composition of menthol, l-arginine and one or more cannabinoids for quickly and reliably providing enhanced pharmacokinetic bioavailability of the cannabinoids to a mammalian subject. The orally dissolvable composition is preferably in the form of a thin orally dissolving mucoadhesive strip or film that is placed in the buccal cavity or under the tongue of a user. The menthol and l-arginine function as permeation enhancers and local vasodilators, providing improved oral transmucosal absorption of the cannabinoids.
Inventors:
THOMPSON RONALD (US)
THOMPSON JAMES (US)
THOMPSON JAMES (US)
Application Number:
PCT/US2019/050902
Publication Date:
July 07, 2022
Filing Date:
September 12, 2019
Export Citation:
Assignee:
CALITAS THERAPEUTICS INC (US)
International Classes:
A61K9/00; A61K31/05; A61K31/352; A61K47/10; A61K47/18
Foreign References:
| US20170290870A1 | 2017-10-12 | |||
| US20110028431A1 | 2011-02-03 | |||
| US20060257463A1 | 2006-11-16 | |||
| US20060039959A1 | 2006-02-23 | |||
| US20160051510A1 | 2016-02-25 |
Attorney, Agent or Firm:
LORUSSO, Mark (US)
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