Title:
ORGANIC-ACID-PRODUCTION PROMOTER, AND AGENT FOR PREVENTING AND/OR AMELIORATE INFLAMMATORY BOWEL DISEASE
Document Type and Number:
WIPO Patent Application WO/2016/103699
Kind Code:
A1
Abstract:
The present invention enhances the organic-acid-production efficiency of bifidobacteria and lactic acid bacteria regardless of the numbers of these beneficial bacteria. The problem is overcome by an organic-acid-production promoter for promoting the production of organic acids through the use of bifidobacteria and lactic acid bacteria containing polyphenol as an active ingredient. Quercetin, taxifolin, phloretin, epigallocatechin gallate, or procyanidin is preferably used as the polyphenol.
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Inventors:
TAMURA AKIRA (JP)
NATSUME MIDORI (JP)
KAWABATA KYUICHI (JP)
NATSUME MIDORI (JP)
KAWABATA KYUICHI (JP)
Application Number:
PCT/JP2015/006425
Publication Date:
June 30, 2016
Filing Date:
December 24, 2015
Export Citation:
Assignee:
MEIJI CO LTD (JP)
International Classes:
A61K31/353; A61K31/12; A61K31/352; A61K35/744; A61K35/745; A61K35/747; A61P1/04; A61P43/00; C12N1/20
Domestic Patent References:
| WO2010101175A1 | 2010-09-10 | |||
| WO2012033151A1 | 2012-03-15 |
Foreign References:
| JP2008195652A | 2008-08-28 | |||
| JP2006273852A | 2006-10-12 | |||
| JP2009084215A | 2009-04-23 | |||
| JP2007217435A | 2007-08-30 | |||
| JP2013147469A | 2013-08-01 | |||
| JPH06166618A | 1994-06-14 | |||
| JP2008500032A | 2008-01-10 |
Other References:
LEE, J. H. ET AL.: "Apple flavonoid phloretin inhibits Escherichia coli 0157:H7 biofilm formation and ameliorates colon inflammation in rats", INFECTION AND IMMUNITY, vol. 79, no. 12, 2011, pages 4819 - 4827
DODDA, D. ET AL.: "Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: possible morphological and biochemical alterations", PHARMACOLOGICAL REPORTS, vol. 66, no. 1, February 2014 (2014-02-01), pages 169 - 173
MOCHIZUKI, M. ET AL.: "Epigallocatechin-3- gallate reduces experimental colon injury in rats by regulating macrophage and mast cell", PHYTOTHERAPY RESEARCH, vol. 24, no. 1, 2010, pages S120 - S122
ZHANG, X. ET AL.: "Fermentation in vitro of EGCG, GCG and EGCG3''Me isolated from Oolong tea by human intestinal microbiota", FOOD RESEARCH INTERNATIONAL, vol. 54, no. 2, 2013, pages 1589 - 1595
KAWABATA, K. ET AL.: "Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin,quercetin, and fisetin", BIOFACTORS, vol. 39, no. 4, 2013, pages 422 - 429
KAWABATA, K. ET AL.: "Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 79, no. 5, May 2015 (2015-05-01), pages 799 - 807
FOGLIANO, V. ET AL.: "In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 55, no. 1, 2011, pages S44 - S55
CURIEL, J. A. ET AL.: "pH and dose-dependent effects of quercetin on the fermentation capacity of Lactobacillus plantarum", LWT - FOOD SCIENCE AND TECHNOLOGY, vol. 43, no. 6, 2010, pages 926 - 933, XP026984679
HUR, S. J. ET AL.: "Review of natural products actions on cytokines in inflammatory bowel disease", NUTRITION RESEARCH, vol. 32, no. 11, 2012, pages 801 - 816, XP002697231, DOI: doi:10.1016/j.nutres.2012.09.013
DODDA, D. ET AL.: "Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: possible morphological and biochemical alterations", PHARMACOLOGICAL REPORTS, vol. 66, no. 1, February 2014 (2014-02-01), pages 169 - 173
MOCHIZUKI, M. ET AL.: "Epigallocatechin-3- gallate reduces experimental colon injury in rats by regulating macrophage and mast cell", PHYTOTHERAPY RESEARCH, vol. 24, no. 1, 2010, pages S120 - S122
ZHANG, X. ET AL.: "Fermentation in vitro of EGCG, GCG and EGCG3''Me isolated from Oolong tea by human intestinal microbiota", FOOD RESEARCH INTERNATIONAL, vol. 54, no. 2, 2013, pages 1589 - 1595
KAWABATA, K. ET AL.: "Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin,quercetin, and fisetin", BIOFACTORS, vol. 39, no. 4, 2013, pages 422 - 429
KAWABATA, K. ET AL.: "Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 79, no. 5, May 2015 (2015-05-01), pages 799 - 807
FOGLIANO, V. ET AL.: "In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 55, no. 1, 2011, pages S44 - S55
CURIEL, J. A. ET AL.: "pH and dose-dependent effects of quercetin on the fermentation capacity of Lactobacillus plantarum", LWT - FOOD SCIENCE AND TECHNOLOGY, vol. 43, no. 6, 2010, pages 926 - 933, XP026984679
HUR, S. J. ET AL.: "Review of natural products actions on cytokines in inflammatory bowel disease", NUTRITION RESEARCH, vol. 32, no. 11, 2012, pages 801 - 816, XP002697231, DOI: doi:10.1016/j.nutres.2012.09.013
Attorney, Agent or Firm:
WATANABE, Kihei et al. (JP)
Kihei Watanabe (JP)
Kihei Watanabe (JP)
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