Title:
OSTEOGENESIS PROMOTING AGENTS
Document Type and Number:
WIPO Patent Application WO/2001/017562
Kind Code:
A1
Abstract:
Osteogenesis promoting agents characterized by containing a compound having an Rho kinase inhibitory activity and a bone inducing factor; and osteogenesis induction potentiating agents characterized by containing a compound having an Rho kinase inhibitory activity as the active ingredient and being capable of potentiating the bone inducing effect of a foreign bone inducing factor. As an example of the compound having an Rho kinase inhibitory activity, (+)-trans-4-(1-aminoethyl)-1-(4-puridylcarbamoyl)cyclohexane may be cited. By using the compound having an Rho kinase inhibitory activity together with the bone inducing factor, the differentiation of mesenchymal cells into osteoblasts is more remarkably induced. The above-described osteogenesis promoting agents and osteogenesis induction potentiating agents are useful in preventing and treating various bone diseases, in particular, bone or cartilage injury, defect or hypogenesis.
Inventors:
ITOH KAZUYUKI (JP)
YOSHIOKA KIYOKO (JP)
YOSHIKAWA HIDEKI (JP)
YOSHIOKA KIYOKO (JP)
YOSHIKAWA HIDEKI (JP)
Application Number:
PCT/JP2000/005871
Publication Date:
March 15, 2001
Filing Date:
August 30, 2000
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
WELFIDE CORP (JP)
ITOH KAZUYUKI (JP)
YOSHIOKA KIYOKO (JP)
YOSHIKAWA HIDEKI (JP)
WELFIDE CORP (JP)
ITOH KAZUYUKI (JP)
YOSHIOKA KIYOKO (JP)
YOSHIKAWA HIDEKI (JP)
International Classes:
A61K31/4409; A61P19/08; A61P19/10; (IPC1-7): A61K45/00; A61K31/27; A61K31/437; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/444; A61K31/4545; A61K31/519; A61P19/08; A61P19/10; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D471/04; C07D487/04; C07D495/04
Domestic Patent References:
| WO1997015308A1 | 1997-05-01 | |||
| WO1998017267A1 | 1998-04-30 | |||
| WO1998006433A1 | 1998-02-19 | |||
| WO1997014681A1 | 1997-04-24 | |||
| WO1999021835A1 | 1999-05-06 | |||
| WO1988000205A1 | 1988-01-14 |
Foreign References:
| US5670514A | 1997-09-23 |
Attorney, Agent or Firm:
Takashima, Hajime (Fushimimachi 4-chome Chuo-ku Osaka-shi Osaka, JP)
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