OXAZOLIDONE DERIVATIVE - EISAI CO LTD

Title:

OXAZOLIDONE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1993/008179

Kind Code:

A1

Abstract:

An oxazolidone derivative represented by general formula (I) and having a monoamine oxidase inhibitory activity, a pharmacologically acceptable salt thereof, and a drug containing the same as the active ingredient for preventing or treating diseases for which a monoamine oxidase inhibitory activity is efficacious. In formula (I) A and B represent each nitrogen, sulfur or oxygen provided that either A or B represents nitrogen; R?1¿ represents a group of formula (a) wherein n and m represent each an integer of 0, 1 to 4; and R?3¿ and R?4¿ represent each hydrogen, hydroxy, lower alkyl, etc.; a group of formula (b) wherein p and q represent each an integer of 0, 1 to 4; and X represents oxygen, sulfur, etc.; a group of formula (c) wherein R?5¿ and R?6¿ represent each hydrogen, cyanoalkyl, etc., or alternatively R?5¿ and R?6¿ are bonded to each other to represent a ring together with the nitrogen atom to which they are bonded; and so forth; R?2¿ represents hydrogen or lower alkyl; and the bond --- represents either a single or a double bond.

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Inventors:

AKASAKA KOZO (JP)
KAJIWARA AKIHARU (JP)
NAGATO SATOSHI (JP)
IIMURA YOUICHI (JP)
YOSHIDA ICHIROU (JP)
SASAKI ATSUSHI (JP)
MIZUNO MASANORI (JP)
KUBOTA ATSUHIKO (JP)
KAGAYA TAKAKI (JP)

Application Number:

PCT/JP1992/001257

Publication Date:

April 29, 1993

Filing Date:

September 30, 1992

Export Citation:

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Assignee:

EISAI CO LTD (JP)

International Classes:

A61K31/423; A61K31/425; A61K31/445; A61P25/24; A61P25/26; A61K31/42; C07D263/56; C07D263/57; C07D263/58; C07D417/04; C07D417/14; (IPC1-7): A61K31/42; A61K31/425; C07D263/56; C07D417/12; C07D417/14

Foreign References:

JPS5753473A

1982-03-30

Other References: